Anti-LNK antibody (ab128222)
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Overview
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Product name
Anti-LNK antibody
See all LNK primary antibodies -
Description
Rabbit polyclonal to LNK -
Host species
Rabbit -
Tested applications
Suitable for: WB, ELISA, IHC-Fr, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Monkey
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Immunogen
Synthetic peptide derived from the C terminal domain of Human LNK.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. -
Storage buffer
Constituents: 1.21% Tris, 0.75% Glycine, 2% Sucrose -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab128222 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/200 - 1/2000. Predicted molecular weight: 63 kDa. | |
| ELISA | Use at an assay dependent concentration. | |
| IHC-Fr | 1/50 - 1/500. | |
| IHC-P | 1/50 - 1/500. |
Target
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Function
Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. -
Tissue specificity
Preferentially expressed by lymphoid cell lines. -
Involvement in disease
Genetic variations in SH2B3 are associated with susceptibility to celiac disease type 13 (CELIAC13)[MIM:612011]; also known as susceptibility to gluten-sensitive enteropathy type 13. Celiac disease is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive.
Genetic variations in SH2B3 are associated with susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100]; also known as diabetes mellitus type 1. IDDM normally starts in childhood or adolescence and is caused by the body's own immune system which destroys the insulin-producing beta cells in the pancreas. Classical features are polydipsia, polyphagia and polyuria, due to hyperglycemia-induced osmotic diuresis. -
Sequence similarities
Belongs to the SH2B adapter family.
Contains 1 PH domain.
Contains 1 SH2 domain. -
Post-translational
modificationsTyrosine phosphorylated by LCK. - Information by UniProt
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Database links
- Entrez Gene: 10019 Human
- Entrez Gene: 16923 Mouse
- Entrez Gene: 58838 Rat
- Omim: 605093 Human
- SwissProt: Q9UQQ2 Human
- SwissProt: O09039 Mouse
- SwissProt: P50745 Rat
- Unigene: 506784 Human
see all -
Alternative names
- IDDM20 antibody
- Lymphocyte adapter protein antibody
- Lymphocyte specific adapter protein antibody
see all
References
ab128222 has not yet been referenced specifically in any publications.
