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    lnk-antibody-ab128222.pdf

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Immunology Adaptive Immunity T Cells Non-CD
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Anti-LNK antibody (ab128222)

  • Datasheet
  • SDS
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Key features and details

  • Rabbit polyclonal to LNK
  • Reacts with: Human
  • Isotype: IgG

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Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-LNK antibody
    See all LNK primary antibodies
  • Description

    Rabbit polyclonal to LNK
  • Host species

    Rabbit
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Monkey
  • Immunogen

    Synthetic peptide derived from the C terminal domain of Human LNK.

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term.
  • Storage buffer

    Constituents: 1.21% Tris, 0.75% Glycine, 2% Sucrose
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Immunology
    • Adaptive Immunity
    • T Cells
    • Non-CD
    • Signal Transduction
    • Adapters
    • Cytoplasmic
    • Signal Transduction
    • Signaling Pathway
    • Lipid Signaling
    • Other

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Target

  • Function

    Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
  • Tissue specificity

    Preferentially expressed by lymphoid cell lines.
  • Involvement in disease

    Genetic variations in SH2B3 are associated with susceptibility to celiac disease type 13 (CELIAC13)[MIM:612011]; also known as susceptibility to gluten-sensitive enteropathy type 13. Celiac disease is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive.
    Genetic variations in SH2B3 are associated with susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100]; also known as diabetes mellitus type 1. IDDM normally starts in childhood or adolescence and is caused by the body's own immune system which destroys the insulin-producing beta cells in the pancreas. Classical features are polydipsia, polyphagia and polyuria, due to hyperglycemia-induced osmotic diuresis.
  • Sequence similarities

    Belongs to the SH2B adapter family.
    Contains 1 PH domain.
    Contains 1 SH2 domain.
  • Post-translational
    modifications

    Tyrosine phosphorylated by LCK.
  • Target information above from: UniProt accession Q9UQQ2 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 10019 Human
    • Entrez Gene: 16923 Mouse
    • Entrez Gene: 58838 Rat
    • Omim: 605093 Human
    • SwissProt: Q9UQQ2 Human
    • SwissProt: O09039 Mouse
    • SwissProt: P50745 Rat
    • Unigene: 506784 Human
    • Unigene: 65493 Mouse
    • Unigene: 11228 Rat
    see all
  • Alternative names

    • IDDM20 antibody
    • Lymphocyte adapter protein antibody
    • Lymphocyte specific adapter protein antibody
    • Lymphocyte specific adapter protein Lnk antibody
    • Lymphocyte-specific adapter protein Lnk antibody
    • SH2B adapter protein 3 antibody
    • SH2B adaptor protein 3 antibody
    • Sh2b3 antibody
    • SH2B3_HUMAN antibody
    • Signal transduction protein Lnk antibody
    see all

Protocols

  • Immunohistochemistry protocols
  • Western blot protocols

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (0)

Publishing research using ab128222? Please let us know so that we can cite the reference in this datasheet.

ab128222 has not yet been referenced specifically in any publications.

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