Anti-LNK antibody (ab128222)

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Key features and details

  • Rabbit polyclonal to LNK
  • Reacts with: Human
  • Isotype: IgG

Overview

  • Product name

    Anti-LNK antibody
    See all LNK primary antibodies

  • Description

    Rabbit polyclonal to LNK

  • Host species

    Rabbit

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Monkey

  • Immunogen

    Synthetic peptide derived from the C terminal domain of Human LNK.

  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

Target

  • Function

    Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.

  • Tissue specificity

    Preferentially expressed by lymphoid cell lines.

  • Involvement in disease

    Genetic variations in SH2B3 are associated with susceptibility to celiac disease type 13 (CELIAC13)[MIM:612011]; also known as susceptibility to gluten-sensitive enteropathy type 13. Celiac disease is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive.
    Genetic variations in SH2B3 are associated with susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100]; also known as diabetes mellitus type 1. IDDM normally starts in childhood or adolescence and is caused by the body's own immune system which destroys the insulin-producing beta cells in the pancreas. Classical features are polydipsia, polyphagia and polyuria, due to hyperglycemia-induced osmotic diuresis.

  • Sequence similarities

    Belongs to the SH2B adapter family.
    Contains 1 PH domain.
    Contains 1 SH2 domain.

  • Post-translational
    modifications

    Tyrosine phosphorylated by LCK.
  • Information by UniProt

  • Database links

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  • Alternative names

    • IDDM20 antibody
    • Lymphocyte adapter protein antibody
    • Lymphocyte specific adapter protein antibody
    • Lymphocyte specific adapter protein Lnk antibody
    • Lymphocyte-specific adapter protein Lnk antibody
    • SH2B adapter protein 3 antibody
    • SH2B adaptor protein 3 antibody
    • Sh2b3 antibody
    • SH2B3_HUMAN antibody
    • Signal transduction protein Lnk antibody
    see all

References (0)

Publishing research using ab128222? Please let us know so that we can cite the reference in this datasheet.

ab128222 has not yet been referenced specifically in any publications.

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