Overview

  • Product name

  • Description

    Rabbit polyclonal to LNK
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ELISA, IHC-Fr, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Monkey
  • Immunogen

    Synthetic peptide derived from the C terminal domain of Human LNK.

Properties

Applications

Our Abpromise guarantee covers the use of ab128222 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/200 - 1/2000. Predicted molecular weight: 63 kDa.
ELISA Use at an assay dependent concentration.
IHC-Fr 1/50 - 1/500.
IHC-P 1/50 - 1/500.

Target

  • Function

    Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.
  • Tissue specificity

    Preferentially expressed by lymphoid cell lines.
  • Involvement in disease

    Genetic variations in SH2B3 are associated with susceptibility to celiac disease type 13 (CELIAC13)[MIM:612011]; also known as susceptibility to gluten-sensitive enteropathy type 13. Celiac disease is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive.
    Genetic variations in SH2B3 are associated with susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100]; also known as diabetes mellitus type 1. IDDM normally starts in childhood or adolescence and is caused by the body's own immune system which destroys the insulin-producing beta cells in the pancreas. Classical features are polydipsia, polyphagia and polyuria, due to hyperglycemia-induced osmotic diuresis.
  • Sequence similarities

    Belongs to the SH2B adapter family.
    Contains 1 PH domain.
    Contains 1 SH2 domain.
  • Post-translational
    modifications

    Tyrosine phosphorylated by LCK.
  • Information by UniProt
  • Database links

  • Alternative names

    • IDDM20 antibody
    • Lymphocyte adapter protein antibody
    • Lymphocyte specific adapter protein antibody
    • Lymphocyte specific adapter protein Lnk antibody
    • Lymphocyte-specific adapter protein Lnk antibody
    • SH2B adapter protein 3 antibody
    • SH2B adaptor protein 3 antibody
    • Sh2b3 antibody
    • SH2B3_HUMAN antibody
    • Signal transduction protein Lnk antibody
    see all

References

ab128222 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab128222.
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