Lofexidine hydrochloride, alpha2-adrenoceptor agonist (ab142906)

Overview

  • Product name

    Lofexidine hydrochloride, alpha2-adrenoceptor agonist
  • Description

    Selective α2-adrenoceptor agonist
  • Biological description

    Selective α2-adrenoceptor agonist (EC50 = 14 μM). Structurally related to clonidine hydrochloride (Asc 753). Shows short-acting antisympathetic and centrally-mediated antiaddiction behavioural effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    21498-08-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[1-(2,6-Dichlorophenoxy)ethyl]-4,5-dihydro-1H-imidazole hydrochloride
  • Molecular weight

    295.60
  • Molecular formula

    C11H12Cl2N2O.HCl
  • PubChem identifier

    30667
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C1=NCCN1)OC2=C(C=CC=C2Cl)Cl.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Kohut SJ  et al. Differential effects of acute and chronic treatment with the a2-adrenergic agonist, lofexidine, on cocaine self-administration in rhesus monkeys. Drug Alcohol Depend : (2013). Read more (PubMed: 23998378) »
  • Gish EC  et al. Lofexidine, an {alpha}2-receptor agonist for opioid detoxification. Ann Pharmacother 44:343-51 (2010). Read more (PubMed: 20040696) »
  • Highfield D  et al. Repeated lofexidine treatment attenuates stress-induced, but not drug cues-induced reinstatement of a heroin-cocaine mixture (speedball) seeking in rats. Neuropsychopharmacology 25:320-31 (2001). Read more (PubMed: 11522461) »

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