Product nameLoganin, ridoid glucoside
DescriptionAntioxidant agent. Cytochrome P450 substrate.
Biological descriptionAntioxidant agent. Cytochrome P450 substrate. Shows potent free-radical-scavenging activity. Selective β-secretase inhibitor. COX-1 inhibitor. Shows neuroprotective effects against Aβ(25-35)-induced and hydrogen peroxide-induced cell death. Shows immunostimulatory, hepatoprotective and neuroprotective effects in vivo. Orally active.
Chemical namemethyl (1S,4aS,6S,7R,7aS)-6-hydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Signal transduction
- Nitric oxide & oxidative stress
This product has been referenced in:
- Babri S et al. Effect of Acute Administration of loganin on Spatial Memory in Diabetic Male Rats. Adv Pharm Bull 3:91-5 (2013). Read more (PubMed: 24312818) »
- Shi J et al. Coumarin glycosides and iridoid glucosides with neuroprotective effects from Hydrangea paniculata. Planta Med 78:1844-50 (2012). Read more (PubMed: 23047248) »
- Kwon SH et al. Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1/2 MAPKs in SH-SY5Y cells. Neurochem Int 58:533-41 (2011). Read more (PubMed: 21241762) »