Overview

  • Product name

    Lomeguatrib, MGMT inhibitor
  • Description

    Potent MGMT inhibitor
  • Biological description

    Potent O6-methylguanine-DNA methyltransferase (MGMT) inhibitor (IC50 = 9 nM). Inhibits recombinant human ATase (IC50 = 5 nM). Shows antitumor effects in vivo. Enhances antitumor effects of temozolomide (ab141055).
  • Purity

    > 98%
  • General notes

    Sold under license from CRT
  • CAS Number

    192441-08-0
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Clemons M  et al. O6-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts. Br J Cancer 93:1152-6 (2005). Read more (PubMed: 16278661) »
  • Barvaux VA  et al. Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA alkyltransferase. Mol Cancer Ther 3:1215-20 (2004). Read more (PubMed: 15486188) »
  • Reinhard J  et al. Monosaccharide-linked inhibitors of O(6)-methylguanine-DNA methyltransferase (MGMT): synthesis, molecular modeling, and structure-activity relationships. J Med Chem 44:4050-61 (2001). Read more (PubMed: 11708909) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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