Lomerizine dihydrochloride, Ca2+ channel blocker (ab142528)

Overview

  • Product name

    Lomerizine dihydrochloride, Ca2+ channel blocker
  • Description

    Ca2+ channel blocker
  • Biological description

    Ca2+ channel blocker. Inhibits voltage-activated inward calcium currents. Shows vasodilatory and neuroprotective effects against ischemic injury in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    101477-54-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[Bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine dihydrochloride
  • Molecular weight

    541.47
  • Molecular formula

    C27H30F2N2O3..2HCl
  • PubChem identifier

    122125
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=C(C(=C(C=C1)CN2CCN(CC2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F)OC)OC.Cl.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Danielisová V & Chavko M Comparative effects of the N-methyl-D-aspartate antagonist MK-801 and the calcium channel blocker KB-2796 on neurologic and metabolic recovery after spinal cord ischemia. Exp Neurol 149:203-8 (1998). Read more (PubMed: 9454629) »
  • Awata N  et al. [Metabolism of lomerizine hydrochloride (KB-2796) in rats]. Yakugaku Zasshi 115:120-9 (1995). Read more (PubMed: 7722879) »
  • Akaike N  et al. Effect of KB-2796, a new diphenylpiperazine Ca2+ antagonist, on voltage-dependent Ca2+ currents and oxidative metabolism in dissociated mammalian CNS neurons. Brain Res 619:263-70 (1993). Read more (PubMed: 8397053) »

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