Overview

  • Product name
    Lomustine, DNA alkylating agent
  • Description
    DNA alkylating agent
  • Biological description
    DNA alkylating and anticancer agent. Induces hepatotoxicity. Cell and blood-brain barrier permeable. Orally active.
  • Purity
    > 98%

Properties

  • Chemical name
    1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
  • Molecular weight
    233.70
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C9H16ClN3O2
  • CAS Number
    13010-47-4
  • PubChem identifier
    3950
  • Storage instructions
    Store at +4°C. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C1CCC(CC1)NC(=O)N(CCCl)N=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Yimam MA  et al. Effects of lipid association on lomustine (CCNU) administered intracerebrally to syngeneic 36B-10 rat brain tumors. Cancer Lett 244:211-9 (2006). Read more (PubMed: 16455196) »
  • Bodor N & Buchwald P Recent advances in the brain targeting of neuropharmaceuticals by chemical delivery systems. Adv Drug Deliv Rev 36:229-254 (1999). Read more (PubMed: 10837718) »
  • Ahmed AE  et al. Studies on the mechanism of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)-induced hepatotoxicity. II. Biochemical and morphological characterization of the injury and its prevention by phenobarbital. Cancer Chemother Pharmacol 19:103-8 (1987). Read more (PubMed: 3105904) »
  • Raghavan KS  et al. Improved delivery through biological membranes. XXX. Synthesis and biological aspects of a 1,4-dihydropyridine based chemical delivery system for brain-sustained delivery of hydroxy CCNU. Anticancer Drug Des 2:25-36 (1987). Read more (PubMed: 3449083) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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