Overview

  • Product name

    Lonidamine, Hexokinase inhibitor
  • Description

    Hexokinase inhibitor
  • Alternative names

    • AF 1890
    • DICA
    • Diclondazolic acid
  • Biological description

    Hexokinase inhibitor (IC50 = 850 μM). Anticancer, antiparasitic and antispermatogenic activity in vivo. Blocks open CFTR Cl- channels in vitro. Orally active.

  • Purity

    > 98%
  • CAS Number

    50264-69-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-[(2,4-Dichlorophenyl)methyl]indazole-3-carboxylic acid
  • Molecular weight

    321.16
  • Molecular formula

    C15H10Cl2N2O2
  • PubChem identifier

    39562
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 10 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C2C(=C1)C(=NN2CC3=C(C=C(C=C3)Cl)Cl)C(=O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Milane L  et al. Pharmacokinetics and biodistribution of lonidamine/paclitaxel loaded, EGFR-targeted nanoparticles in an orthotopic animal model of multi-drug resistant breast cancer. Nanomedicine 7:435-44 (2011). Read more (PubMed: 21220050) »
  • Chambers JW  et al. The anti-trypanosomal agent lonidamine inhibits Trypanosoma brucei hexokinase 1. Mol Biochem Parasitol 158:202-7 (2008). Read more (PubMed: 18262292) »
  • Traina ME  et al. Lonidamine transiently affects spermatogenesis in pubertal CD1 mice. Contraception 72:262-7 (2005). Read more (PubMed: 16181969) »
  • Gong X  et al. Mechanism of lonidamine inhibition of the CFTR chloride channel. Br J Pharmacol 137:928-36 (2002). Read more (PubMed: 12411425) »

Customer reviews and Q&As

Answer

The DMSO and HCl should not degrade/affect the quality of the Ionidamin.

As some products may be difficult to solubilise, we recommend that rapid stirring, warming in a water bath, or sonication of the solution may help.

Read More

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