Anti-LONP1/Lon antibody (ab103809)
Key features and details
- Rabbit polyclonal to LONP1/Lon
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-LONP1/Lon antibody
See all LONP1/Lon primary antibodies -
Description
Rabbit polyclonal to LONP1/Lon -
Host species
Rabbit -
Tested Applications & Species
Application Species WB MouseHuman -
Immunogen
Recombinant full length protein corresponding to Human LONP1/Lon aa 1-959.
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Positive control
- Human kidney, Mouse kidney, HepG2, transfected 293T cell line
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General notes
Protein previously labeled as LONP1.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.4
Constituent: PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab103809 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
Application | Species |
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WB |
Mouse
Human
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Application | Abreviews | Notes |
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WB | (1) |
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 106 kDa.
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Notes |
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WB
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 106 kDa. |
Target
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Function
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein. -
Tissue specificity
Duodenum, heart, lung and liver, but not thymus. -
Involvement in disease
CODAS syndrome -
Sequence similarities
Belongs to the peptidase S16 family.
Contains 1 Lon domain. -
Cellular localization
Mitochondrion matrix. - Information by UniProt
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Database links
- Entrez Gene: 9361 Human
- Entrez Gene: 74142 Mouse
- Omim: 605490 Human
- SwissProt: P36776 Human
- SwissProt: Q8CGK3 Mouse
- Unigene: 350265 Human
- Unigene: 329136 Mouse
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Alternative names
- hLON antibody
- hLON ATP dependent protease antibody
- LON antibody
see all
Images
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Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml + Human kidney tissue lysate at 50 µg
Predicted band size: 106 kDa -
Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml + Mouse kidney tissue lysate at 50 µg
Predicted band size: 106 kDa -
Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml + HepG2 cell lysate at 50 µg
Predicted band size: 106 kDa -
All lanes : Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml
Lane 1 : LONP1 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 106 kDa
Datasheets and documents
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SDS download
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Datasheet download
References (15)
ab103809 has been referenced in 15 publications.
- Burstein SR et al. In vitro and in vivo studies of the ALS-FTLD protein CHCHD10 reveal novel mitochondrial topology and protein interactions. Hum Mol Genet 27:160-177 (2018). PubMed: 29112723
- Agnew T et al. A Wars2 Mutant Mouse Model Displays OXPHOS Deficiencies and Activation of Tissue-Specific Stress Response Pathways. Cell Rep 25:3315-3328.e6 (2018). PubMed: 30566859
- Liu J et al. Aerobic Exercise Preconception and During Pregnancy Enhances Oxidative Capacity in the Hindlimb Muscles of Mice Offspring. J Strength Cond Res 32:1391-1403 (2018). PubMed: 29309390
- Song M et al. Abrogating Mitochondrial Dynamics in Mouse Hearts Accelerates Mitochondrial Senescence. Cell Metab 26:872-883.e5 (2017). PubMed: 29107503
- Wiechmann K et al. Mitochondrial Chaperonin HSP60 Is the Apoptosis-Related Target for Myrtucommulone. Cell Chem Biol 24:614-623.e6 (2017). PubMed: 28457707