Anti-LONP1/Lon antibody (ab103809)
Key features and details
- Rabbit polyclonal to LONP1/Lon
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
Overview
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Product name
Anti-LONP1/Lon antibody
See all LONP1/Lon primary antibodies -
Description
Rabbit polyclonal to LONP1/Lon -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse, Human -
Immunogen
Recombinant full length protein corresponding to Human LONP1/Lon aa 1-959.
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Positive control
- Human kidney, Mouse kidney, HepG2, transfected 293T cell line
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.4
Constituent: PBS -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab103809 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB | (2) |
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 106 kDa.
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Notes |
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WB
Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 106 kDa. |
Target
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Function
ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein. -
Tissue specificity
Duodenum, heart, lung and liver, but not thymus. -
Involvement in disease
CODAS syndrome -
Sequence similarities
Belongs to the peptidase S16 family.
Contains 1 Lon domain. -
Cellular localization
Mitochondrion matrix. - Information by UniProt
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Database links
- Entrez Gene: 9361 Human
- Entrez Gene: 74142 Mouse
- Omim: 605490 Human
- SwissProt: P36776 Human
- SwissProt: Q8CGK3 Mouse
- Unigene: 350265 Human
- Unigene: 329136 Mouse
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Alternative names
- hLON antibody
- hLON ATP dependent protease antibody
- LON antibody
see all
Images
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Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml + Human kidney tissue lysate at 50 µg
Predicted band size: 106 kDa -
Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml + Mouse kidney tissue lysate at 50 µg
Predicted band size: 106 kDa -
Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml + HepG2 cell lysate at 50 µg
Predicted band size: 106 kDa -
All lanes : Anti-LONP1/Lon antibody (ab103809) at 5 µg/ml
Lane 1 : LONP1 transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 106 kDa
Datasheets and documents
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Datasheet download
References (24)
ab103809 has been referenced in 24 publications.
- Chattopadhyay M et al. The portrait of liver cancer is shaped by mitochondrial genetics. Cell Rep 38:110254 (2022). PubMed: 35045282
- Cai G et al. Rosmarinic Acid Inhibits Mitochondrial Damage by Alleviating Unfolded Protein Response. Front Pharmacol 13:859978 (2022). PubMed: 35652041
- Zanini G et al. Differential Expression of Lonp1 Isoforms in Cancer Cells. Cells 11:N/A (2022). PubMed: 36497197
- Gao X et al. ATF5, a putative therapeutic target for the mitochondrial DNA 3243A > G mutation-related disease. Cell Death Dis 12:701 (2021). PubMed: 34262025
- Lee Y et al. General anesthesia activates the mitochondrial unfolded protein response and induces age-dependent, long-lasting changes in mitochondrial function in the developing brain. Neurotoxicology 82:1-8 (2021). PubMed: 33144179