Overview

  • Product name

  • Description

    Rabbit polyclonal to LONP1/Lon
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human LONP1/Lon aa 389-418 (internal sequence) conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary. NP_004784.2.
    Sequence:

    QTHRKYLLQEQLKIIKKELGLEKDDKDAIE


    Database link: P36776

  • Positive control

    • Human heart tissue; HeLa cell lysate.
  • General notes

    Protein previously labeled as LONP1.

Properties

Applications

Our Abpromise guarantee covers the use of ab211281 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 106 kDa.
IHC-P 1/100. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters. Endogenous substrates include mitochondrial steroidogenic acute regulatory (StAR) protein.
  • Tissue specificity

    Duodenum, heart, lung and liver, but not thymus.
  • Involvement in disease

    CODAS syndrome
  • Sequence similarities

    Belongs to the peptidase S16 family.
    Contains 1 Lon domain.
  • Cellular localization

    Mitochondrion matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • hLON antibody
    • hLON ATP dependent protease antibody
    • LON antibody
    • lon peptidase 1, mitochondrial antibody
    • LON protease antibody
    • Lon protease homolog antibody
    • Lon protease like protein antibody
    • Lon protease-like protein antibody
    • LONHs antibody
    • LONM_HUMAN antibody
    • LONP antibody
    • Lonp1 antibody
    • MGC1498 antibody
    • mitochondrial antibody
    • Mitochondrial ATP dependent protease Lon antibody
    • Mitochondrial ATP-dependent protease Lon antibody
    • Mitochondrial lon peptidase 1 antibody
    • PIM1 antibody
    • Protease serine 15 antibody
    • PRSS15 antibody
    • Serine protease 15 antibody
    see all

Images

  • Anti-LONP1/Lon antibody (ab211281) at 1/1000 dilution + HeLa cell lysate at 35 µg

    Predicted band size: 106 kDa

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human heart tissue labeling LONP1/Lon with ab211281 at 1/100 dilution.

     

References

ab211281 has not yet been referenced specifically in any publications.

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