Lorglumide sodium salt, cholecystokinin receptor antagonist (ab141319)

Overview

  • Product name

    Lorglumide sodium salt, cholecystokinin receptor antagonist
  • Description

    Potent, selective cholecystokinin receptor antagonist
  • Biological description

    Potent, selective cholecystokinin A (CCKA) receptor antagonist. Inhibits the stimulating effect of cholecystokinin on pancreatic growth, lesions and carcinogenesis.
  • Purity

    > 98%
  • CAS Number

    1021868-76-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    Sodium 4-[(3,4-dichlorobenzoyl)amino]-5-(dipentylamino)-5-oxopentanoate
  • Molecular weight

    481.39
  • Molecular formula

    C22H31Cl2N2NaO4
  • PubChem identifier

    23681233
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCN(CCCCC)C(=O)C(CCC(=O)[O-])NC(=O)C1=CC(=C(C=C1)Cl)Cl.[Na+]
  • Source

    Synthetic

References

This product has been referenced in:

  • Sperti C  et al. Effect of cholecystokinin analogue caerulein and cholecystokinin antagonist lorglumide on pancreatic carcinogenesis in the rat. J Surg Oncol 57:11-6 (1994). Read more (PubMed: 8065144) »
  • Meijers M  et al. Effects of cholecystokinin and bombesin on development of azaserine-induced pancreatic tumours in rats: modulation by the cholecystokinin receptor antagonist lorglumide. Carcinogenesis 13:1525-8 (1992). Read more (PubMed: 1394835) »
  • van der Bent A  et al. Hybrid cholecystokinin-A antagonists based on molecular modeling of lorglumide and L-364,718. J Med Chem 35:1042-9 (1992). Read more (PubMed: 1552499) »

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