Overview

  • Product name

    Anti-Loricrin antibody - Aminoterminal end
    See all Loricrin primary antibodies
  • Description

    Rabbit polyclonal to Loricrin - Aminoterminal end
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide, corresponding to a region within N terminal amino acids 1-46 of Human Loricrin (NP_000418).

  • Positive control

    • 293T, A431, H1299, HeLa, HepG2, Molt-4, Raji whole cell lysates, Hep3B cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab137533 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 26 kDa.
ICC/IF 1/100 - 1/1000.

Target

  • Function

    Major keratinocyte cell envelope protein.
  • Involvement in disease

    Defects in LOR are a cause of progressive symmetric erythrokeratodermia (PSEK) [MIM:133200]. Erythrokeratodermas are a group of disorders characterized by widespread erythematous plaques, either stationary or migratory, associated with features that include palmoplantar keratoderma. PSEK is characterized by erythematous and hyperkeratotic plaques.
    Defects in LOR are the cause of Vohwinkel syndrome with ichthyosis (VSI) [MIM:604117]; also known as loricrin keratoderma (LK) or mutilating keratoderma with ichthyosis. VSI is an ichthyotic variant of Vohwinkel syndrome (VS) characterized by progressive symmetric erythrokeratoderma or congenital ichthyosiform erythroderma born as a collodion baby. Common clinical features include hyperkeratosis of the palms and soles with digital constriction.
  • Post-translational
    modifications

    Substrate of transglutaminases. Some glutamines and lysines are cross-linked to other loricrin molecules and to SPRRs proteins.
    Contains inter- or intramolecular disulfide-bonds.
  • Cellular localization

    Cytoplasm. Nucleus > nucleoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • LOR antibody
    • LOR protein antibody
    • LORI_HUMAN antibody
    • Loricrin antibody
    • LRN antibody
    • MGC111513 antibody
    • OTTHUMP00000015823 antibody
    see all

Images

  • Anti-Loricrin antibody - Aminoterminal end (ab137533) at 1/1000 dilution + Raji whole cell lysate at 30 µg

    Predicted band size: 26 kDa



    12% SDS PAGE
  • Immunofluorescence analysis of methanol fixed Hep3B cells, labelling Loricrin with ab137533 at 1/500. The lower panel shows costaing with Hoechst 33342.

References

ab137533 has not yet been referenced specifically in any publications.

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