• Product name

    Anti-Loricrin antibody [EPR7148(2)(B)]
    See all Loricrin primary antibodies
  • Description

    Rabbit monoclonal [EPR7148(2)(B)] to Loricrin
  • Host species

  • Tested applications

    Suitable for: IHC-P, WBmore details
    Unsuitable for: ICC or IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Loricrin aa 1-100. The exact sequence is proprietary.
    Database link: P23490

  • Positive control

    • Human skin lysate and Human skin tissue.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.


    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab176322 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/250 - 1/500.
WB 1/10000 - 1/50000. Predicted molecular weight: 26 kDa.
  • Application notes
    Is unsuitable for ICC or IP.
  • Target

    • Function

      Major keratinocyte cell envelope protein.
    • Involvement in disease

      Defects in LOR are a cause of progressive symmetric erythrokeratodermia (PSEK) [MIM:133200]. Erythrokeratodermas are a group of disorders characterized by widespread erythematous plaques, either stationary or migratory, associated with features that include palmoplantar keratoderma. PSEK is characterized by erythematous and hyperkeratotic plaques.
      Defects in LOR are the cause of Vohwinkel syndrome with ichthyosis (VSI) [MIM:604117]; also known as loricrin keratoderma (LK) or mutilating keratoderma with ichthyosis. VSI is an ichthyotic variant of Vohwinkel syndrome (VS) characterized by progressive symmetric erythrokeratoderma or congenital ichthyosiform erythroderma born as a collodion baby. Common clinical features include hyperkeratosis of the palms and soles with digital constriction.
    • Post-translational

      Substrate of transglutaminases. Some glutamines and lysines are cross-linked to other loricrin molecules and to SPRRs proteins.
      Contains inter- or intramolecular disulfide-bonds.
    • Cellular localization

      Cytoplasm. Nucleus > nucleoplasm.
    • Information by UniProt
    • Database links

    • Alternative names

      • LOR antibody
      • LOR protein antibody
      • LORI_HUMAN antibody
      • Loricrin antibody
      • LRN antibody
      • MGC111513 antibody
      • OTTHUMP00000015823 antibody
      see all


    • Anti-Loricrin antibody [EPR7148(2)(B)] (ab176322) at 1/10000 dilution + Human skin lysate at 10 µg

      Predicted band size: 26 kDa

    • Immunohistochemical analysis of paraffin-embedded Human skin tissue labeling Loricrin using ab176322 at a 1/250 dilution.


    ab176322 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab176322.
    Please use the links above to contact us or submit feedback about this product.

    For licensing inquiries, please contact partnerships@abcam.com

    Sign up