Overview

  • Product name
    Anti-Loricrin antibody [EPR7148(2)(B)]
    See all Loricrin primary antibodies
  • Description
    Rabbit monoclonal [EPR7148(2)(B)] to Loricrin
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-P, WBmore details
    Unsuitable for: ICC or IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human Loricrin aa 1-100. The exact sequence is proprietary.
    Database link: P23490

  • Positive control
    • Human skin lysate and Human skin tissue.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab176322 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/250 - 1/500.
WB 1/10000 - 1/50000. Predicted molecular weight: 26 kDa.
  • Application notes
    Is unsuitable for ICC or IP.
  • Target

    • Function
      Major keratinocyte cell envelope protein.
    • Involvement in disease
      Defects in LOR are a cause of progressive symmetric erythrokeratodermia (PSEK) [MIM:133200]. Erythrokeratodermas are a group of disorders characterized by widespread erythematous plaques, either stationary or migratory, associated with features that include palmoplantar keratoderma. PSEK is characterized by erythematous and hyperkeratotic plaques.
      Defects in LOR are the cause of Vohwinkel syndrome with ichthyosis (VSI) [MIM:604117]; also known as loricrin keratoderma (LK) or mutilating keratoderma with ichthyosis. VSI is an ichthyotic variant of Vohwinkel syndrome (VS) characterized by progressive symmetric erythrokeratoderma or congenital ichthyosiform erythroderma born as a collodion baby. Common clinical features include hyperkeratosis of the palms and soles with digital constriction.
    • Post-translational
      modifications
      Substrate of transglutaminases. Some glutamines and lysines are cross-linked to other loricrin molecules and to SPRRs proteins.
      Contains inter- or intramolecular disulfide-bonds.
    • Cellular localization
      Cytoplasm. Nucleus > nucleoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • LOR antibody
      • LOR protein antibody
      • LORI_HUMAN antibody
      • Loricrin antibody
      • LRN antibody
      • MGC111513 antibody
      • OTTHUMP00000015823 antibody
      see all

    Images

    • Anti-Loricrin antibody [EPR7148(2)(B)] (ab176322) at 1/10000 dilution + Human skin lysate at 10 µg

      Predicted band size: 26 kDa

    • Immunohistochemical analysis of paraffin-embedded Human skin tissue labeling Loricrin using ab176322 at a 1/250 dilution.

    References

    ab176322 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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