Overview

  • Product name

    Lornoxicam, COX-1 and COX-2 inhibitor
  • Description

    Potent COX-1 and COX-2 inhibitor
  • Biological description

    Potent COX-1 and COX-2 inhibitor (IC50 = 5 and 8 nM for COX-1 and COX-2, respectively). Inhibits IL-6 production and reduces nitric oxide formation. Reduces c-Fos expression in vivo. Orally active. Anti-inflammatory agent. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    70374-39-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-Chloro-4-hydroxy-2-methyl-1,1-dioxo-N-pyridin-2-ylthieno[2,3-e]thiazine-3-carboxamide
  • Molecular weight

    371.82
  • Molecular formula

    C13H10ClN3O4S2
  • PubChem identifier

    54690031
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Bianchi M & Panerai AE Effects of lornoxicam, piroxicam, and meloxicam in a model of thermal hindpaw hyperalgesia induced by formalin injection in rat tail. Pharmacol Res 45:101-5 (2002). Read more (PubMed: 11846620) »
  • Berg J  et al. The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitro. Inflamm Res 48:369-79 (1999). Read more (PubMed: 10450786) »
  • Buritova J & Besson JM Dose-related anti-inflammatory/analgesic effects of lornoxicam: a spinal c-Fos protein study in the rat. Inflamm Res 47:18-25 (1998). Read more (PubMed: 9495582) »

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