Losartan potassium, non-peptide angiotensin II AT1 receptor antagonist (ab120997)

Overview

  • Product name

    Losartan potassium, non-peptide angiotensin II AT1 receptor antagonist
  • Description

    Selective non-peptide angiotensin II AT1 receptor antagonist
  • Biological description

    Selective non-peptide angiotensin II type 1 (AT1) receptor antagonist (Ki = 10 nM). Blocks classical actions of angiotensin II (ab120183). Displays antihypertensive action and downregulates TFG-β regulation. Active in vivo.
  • Purity

    > 99%
  • CAS Number

    124750-99-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Habashi JP  et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science 312:117-21 (2006). Read more (PubMed: 16601194) »
  • Guo ZX & Qiu MC [Losartan downregulates the expression of transforming growth factor beta type I and type II receptors in kidney of diabetic rat]. Zhonghua Nei Ke Za Zhi 42:403-8 (2003). Read more (PubMed: 12895325) »
  • García-Sáinz JA  et al. Characterization of the AT1 angiotensin II receptor expressed in guinea pig liver. J Endocrinol 154:133-8 (1997). Read more (PubMed: 9246947) »
  • Ji H  et al. Differential structural requirements for specific binding of nonpeptide and peptide antagonists to the AT1 angiotensin receptor. Identification of amino acid residues that determine binding of the antihypertensive drug losartan. J Biol Chem 269:16533-6 (1994). Read more (PubMed: 8206967) »
See all 4 Publications for this product

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