Loxapine succinate, D2/D4 dopamine receptor inhibitor (ab145823)

Overview

  • Product name

    Loxapine succinate, D2/D4 dopamine receptor inhibitor
  • Description

    D2/D4 dopamine receptor inhibitor. Serotonin receptor antagonist. Dibenzoxazepine antipsychotic agent.
  • Alternative names

    • 8-Chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine succinate
    • Loxapine
    • Loxapine succinate salt
  • Biological description

    D2/D4 dopamine receptor inhibitor. Serotonin receptor antagonist. Dibenzoxazepine antipsychotic agent.

  • CAS Number

    27833-64-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    8-Chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine succinate
  • Molecular weight

    445.90
  • Molecular formula

    C18H18ClN3O.C4H6O4
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 4 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Labuzek K  et al. Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Eur Neuropsychopharmacol 15:23-30 (2005). Read more (PubMed: 15572270) »
  • Kalkman HO  et al. Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats. Naunyn Schmiedebergs Arch Pharmacol 355:361-4 (1997). Read more (PubMed: 9089667) »
  • Singh AN  et al. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. J Psychiatry Neurosci 21:29-35 (1996). Read more (PubMed: 8580115) »
  • Lee T & Tang SW Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain. Psychiatry Res 12:277-85 (1984). Read more (PubMed: 6239298) »
  • Branchey MH  et al. Loxapine succinate as a neuroleptic agent: evaluation in two populations of elderly psychiatric patients. J Am Geriatr Soc 26:263-7 (1978). Read more (PubMed: 757995) »

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