Product nameLoxapine succinate, D2/D4 dopamine receptor inhibitor
DescriptionD2/D4 dopamine receptor inhibitor. Serotonin receptor antagonist. Dibenzoxazepine antipsychotic agent.
- 8-Chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine succinate
- Loxapine succinate salt
D2/D4 dopamine receptor inhibitor. Serotonin receptor antagonist. Dibenzoxazepine antipsychotic agent.
Chemical name8-Chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine succinate
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 4 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Labuzek K et al. Chlorpromazine and loxapine reduce interleukin-1beta and interleukin-2 release by rat mixed glial and microglial cell cultures. Eur Neuropsychopharmacol 15:23-30 (2005). Read more (PubMed: 15572270) »
- Kalkman HO et al. Clozapine inhibits catalepsy induced by olanzapine and loxapine, but prolongs catalepsy induced by SCH 23390 in rats. Naunyn Schmiedebergs Arch Pharmacol 355:361-4 (1997). Read more (PubMed: 9089667) »
- Singh AN et al. A neurochemical basis for the antipsychotic activity of loxapine: interactions with dopamine D1, D2, D4 and serotonin 5-HT2 receptor subtypes. J Psychiatry Neurosci 21:29-35 (1996). Read more (PubMed: 8580115) »
- Lee T & Tang SW Loxapine and clozapine decrease serotonin (S2) but do not elevate dopamine (D2) receptor numbers in the rat brain. Psychiatry Res 12:277-85 (1984). Read more (PubMed: 6239298) »
- Branchey MH et al. Loxapine succinate as a neuroleptic agent: evaluation in two populations of elderly psychiatric patients. J Am Geriatr Soc 26:263-7 (1978). Read more (PubMed: 757995) »