Overview

  • Product name

    Loxoprofen sodium dihydrate, Cycloxygenase inhibitor
  • Description

    Cycloxygenase inhibitor
  • Biological description

    Cycloxygenase inhibitor (IC50 values are 25 and 10 µM for COX-1 and COX-2 respectively). Non-steroidal anti-inflamatory drug (NSAID). Cell-permeable. Orally active.
  • Purity

    > 98%
  • CAS Number

    226721-96-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propanoate sodium salt dihydrate

  • Molecular weight

    304.32
  • Molecular formula

    C15H17NaO3.2H2O
  • PubChem identifier

    23674745
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C1=CC=C(C=C1)CC2CCCC2=O)C(=O)[O-].O.O.[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Yamakawa N  et al. Synthesis and biological evaluation of loxoprofen derivatives. Bioorg Med Chem 19:3299-311 (2011). Read more (PubMed: 21570308) »
  • Yamakawa N  et al. Properties and synthesis of 2-{2-fluoro (or bromo)-4-[(2-oxocyclopentyl)methyl]phenyl}propanoic acid: nonsteroidal anti-inflammatory drugs with low membrane permeabilizing and gastric lesion-producing activities. J Med Chem 53:7879-82 (2010). Read more (PubMed: 20954731) »
  • Sekiguchi M  et al. Analgesic effect of percutaneously absorbed non-steroidal anti-inflammatory drugs: an experimental study in a rat acute inflammation model. BMC Musculoskelet Disord 9:15 (2008). Read more (PubMed: 18234123) »
  • Koo TS  et al. Comparison of pharmacokinetics of loxoprofen and its active metabolites after an intravenous, intramuscular, and oral administration of loxoprofen in rats: evidence for extrahepatic metabolism. J Pharm Sci 94:2187-97 (2005). Read more (PubMed: 16136574) »

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