Loxoribine (RW-J-21757), Toll-like receptor 7 (TLR7) agonist (ab142187)

Overview

  • Product name

    Loxoribine (RW-J-21757), Toll-like receptor 7 (TLR7) agonist
  • Description

    Toll-like receptor 7 (TLR7) agonist
  • Biological description

    Toll-like receptor 7 (TLR7) agonist. Induces immune cell activation and cytokine production. Displays antitumor activity in vivo.
  • Purity

    > 97%
  • CAS Number

    121288-39-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Amino-9-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-7-prop-2-enyl-3H-purine-6,8-dione
  • Molecular weight

    339.30
  • Molecular formula

    C13H17N5O6
  • PubChem identifier

    60737
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 75 mM and in water to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C=CCN1C2=C(NC(=NC2=O)N)N(C1=O)C3C(C(C(O3)CO)O)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Heil F  et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol 33:2987-97 (2003). Read more (PubMed: 14579267) »
  • Pope BL  et al. The immunostimulatory compound 7-allyl-8-oxoguanosine (loxoribine) induces a distinct subset of murine cytokines. Cell Immunol 162:333-9 (1995). Read more (PubMed: 7743561) »
  • Goodman MG & Goodman JH Topology of the loxoribine binding site. Studies with inactive loxoribine analogues. J Immunol 153:4081-7 (1994). Read more (PubMed: 7930614) »

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