Key features and details
- Rabbit polyclonal to LPA-2
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-LPA-2 antibody
See all LPA-2 primary antibodies
DescriptionRabbit polyclonal to LPA-2
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Synthetic peptide corresponding to Human LPA-2 (C terminal).
- COLO205 cell lysate
Protein previously labeled as EDG4.
Storage instructionsShipped at 4°C. Store at -20ºC.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride
without Mg2+ and Ca2+
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab135980 was affinity-purified from rabbit anti-serum by immunogenic peptide affinity-chromatography.
Our Abpromise guarantee covers the use of ab135980 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 39 kDa.|
FunctionReceptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation.
Tissue specificityExpressed most abundantly in testes and peripheral blood leukocytes with less expression in pancreas, spleen, thymus and prostate. Little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Cellular localizationCell surface. Cell membrane. Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
- Information by UniProt
- EDG 4 antibody
- EDG-4 antibody
- EDG4 antibody
ab135980 has been referenced in 1 publication.
- Ren Z et al. Lysophosphatidic acid induces the migration and invasion of SGC-7901 gastric cancer cells through the LPA2 and Notch signaling pathways. Int J Mol Med 44:67-78 (2019). PubMed: 31115486