Overview

  • Product name

  • Description

    Rabbit polyclonal to LPA-3
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Horse, Hamster, Cow, Dog, Monkey, Gorilla, Bat
  • Immunogen

    Synthetic peptide corresponding to Human LPA-3. (15 amino acid peptide from 2nd cytoplasmic domain)
    Database link: Q9UBY5

  • Positive control

    • Human prostate carcinoma, heart myocardial infarct, brain amygdala and colon carcinoma tissues.
  • General notes

    Protein previously labeled as EDG7.

Properties

Applications

Our Abpromise guarantee covers the use of ab219267 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 4 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
  • Tissue specificity

    Most abundantly expressed in prostate, testes, pancreas, and heart, with moderate levels in lung and ovary. No detectable expression in brain, placenta, liver, skeletal muscle, kidney, spleen, thymus, small intestine, colon, or peripheral blood leukocytes.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Calcium mobilizing lysophosphatidic acid receptor LP A3 antibody
    • Calcium mobilizing lysophosphatidic acid receptor LPA 3 antibody
    • Calcium mobilizing lysophosphatidic acid receptor LPA3 antibody
    • EDG 7 antibody
    • Endothelial cell differentiation gene 7 antibody
    • Endothelial differentiation lysophosphatidic acid G protein coupled receptor 7 antibody
    • FLJ98231 antibody
    • GPCR antibody
    • HOFNH 30 antibody
    • HOFNH30 antibody
    • LP A3 antibody
    • LPA 3 antibody
    • LPA receptor 3 antibody
    • LPA receptor EDG 7 antibody
    • LPA receptor EDG7 antibody
    • LPA-3 antibody
    • LPA3 antibody
    • LPAR 3 antibody
    • Lpar3 antibody
    • LPAR3_HUMAN antibody
    • Lysophosphatidic acid receptor 3 antibody
    • Lysophosphatidic acid receptor Edg 7 antibody
    • Lysophosphatidic acid receptor Edg-7 antibody
    • Lysophosphatidic acid receptor Edg7 antibody
    • OTTHUMP00000011573 antibody
    • RP4 678I3 antibody
    • RP4678I3 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded human Prostate carcinoma tissue labeling LPA-3 with ab219267 at 4 µg/ml.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded human heart, myocardial infarct tissue labeling LPA-3 with ab219267 at 4 µg/ml.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded human brain, amygdala tissue labeling LPA-3 with ab219267 at 4 µg/ml.

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded human colon carcinoma tissue labeling LPA-3 with ab219267 at 4 µg/ml.

References

This product has been referenced in:

  • Zhang G  et al. ATX-LPA axis facilitates estrogen-induced endometrial cancer cell proliferation via MAPK/ERK signaling pathway. Mol Med Rep 17:4245-4252 (2018). Read more (PubMed: 29328374) »
See 1 Publication for this product

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