Overview

  • Product name

  • Description

    Rabbit polyclonal to LPA-4
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Hamster, Gorilla, Common marmoset, Bat
  • Immunogen

    Synthetic peptide corresponding to Human LPA-4 (C terminal) conjugated to keyhole limpet haemocyanin.

  • Positive control

    • Human Brain, Cortex tissue
  • General notes

    Previously labelled as P2Y9. 

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -80ºC. Avoid freeze / thaw cycles.
  • Storage buffer

    Preservative: 0.01% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab115454 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 20 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB Use at an assay dependent concentration. Predicted molecular weight: 42 kDa. PubMed: 24396418

Target

  • Function

    Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Transduces a signal by increasing the intracellular calcium ions and by stimulating adenylyl cyclase activity. The rank order of potency for agonists of this receptor is 1-oleoyl- > 1-stearoyl- > 1-palmitoyl- > 1-myristoyl- > 1-alkyl- > 1-alkenyl-LPA.
  • Tissue specificity

    High expression in ovary. Not detected in the brain regions thalamus, putamen, caudate, frontal cortex, pons, hypothalamus and hippocampus.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 5730485F04Rik antibody
    • G protein coupled receptor 23 antibody
    • G-protein coupled receptor 23 antibody
    • GPR23 antibody
    • LPA receptor 4 antibody
    • LPA-4 antibody
    • LPA4 antibody
    • Lpar4 antibody
    • LPAR4_HUMAN antibody
    • Lysophosphatidic acid receptor 4 antibody
    • Lysophosphatidic Acid Receptor P2Y9 antibody
    • P2RY9 antibody
    • P2Y purinoceptor 9 antibody
    • P2Y5 like antibody
    • P2Y5-like receptor antibody
    • P2Y9 antibody
    • Purinergic receptor 9 antibody
    • Purinergic receptor, P2Y, G-protein coupled, 9 antibody
    see all

Images

  • ab115454, at 20 µg/ml, staining LPA-4 in formalin-fixed, paraffin-embedded Human Brain, Cortex tissue by Immunohistochemistry, using a biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

References

This product has been referenced in:

  • Feng Y & Liu JF Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter. Exp Ther Med 7:423-428 (2014). WB ; Human . Read more (PubMed: 24396418) »
See 1 Publication for this product

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