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    lpcat3-antibody-ab223070.pdf

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Signal Transduction Metabolism Lipid metabolism
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Anti-LPCAT3 antibody (ab223070)

  • Datasheet
  • SDS
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LPCAT3 antibody (ab223070)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LPCAT3 antibody (ab223070)

Key features and details

  • Rabbit polyclonal to LPCAT3
  • Suitable for: IHC-P
  • Reacts with: Human
  • Isotype: IgG

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Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-LPCAT3 antibody
    See all LPCAT3 primary antibodies
  • Description

    Rabbit polyclonal to LPCAT3
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Rat
  • Immunogen

    Recombinant fragment corresponding to Human LPCAT3 aa 306-363.
    Sequence:

    EEKGKAKWDACANMKVWLFETNPRFTGTIASFNINTNAWVARYIFKRLKF LGNKELSQ


    Database link: Q6P1A2
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • Positive control

    • IHC-P: Human liver and pancreatic tissues.
  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.40
    Constituents: 50% Glycerol (glycerin, glycerine), PBS, 0.03% Proclin 300
  • Concentration information loading...
  • Purity

    Protein G purified
  • Purification notes

    Purity >95%
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Metabolism
    • Lipid metabolism
    • Metabolism
    • Pathways and Processes
    • Metabolic signaling pathways
    • Lipid and lipoprotein metabolism
    • Lipid metabolism

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

Our Abpromise guarantee covers the use of ab223070 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    Acyltransferase which mediates the conversion of lysophosphatidylcholine (1-acyl-sn-glycero-3-phosphocholine or LPC) into phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine or PC) (LPCAT activity). Catalyzes also the conversion of lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) into phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine or PS) (LPSAT activity). Has also weak lysophosphatidylethanolamine acyltransferase activity (LPEAT activity). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs. Seems to be the major enzyme contributing to LPCAT activity in the liver. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle.
  • Tissue specificity

    Highly expressed in liver, pancreas and adipose tissue. Very low expression in skeletal muscle and heart. Detected in neutrophils.
  • Pathway

    Lipid metabolism; phospholipid metabolism.
  • Sequence similarities

    Belongs to the membrane-bound acyltransferase family.
  • Domain

    The di-lysine motif confers endoplasmic reticulum localization.
  • Cellular localization

    Endoplasmic reticulum membrane.
  • Target information above from: UniProt accession Q6P1A2 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 10162 Human
    • SwissProt: Q6P1A2 Human
    • Unigene: 655248 Human
    • Alternative names

      • 1-acylglycerophosphocholine O-acyltransferase antibody
      • 1-acylglycerophosphoserine O-acyltransferase antibody
      • LPCAT antibody
      • Lpcat3 antibody
      • LPLAT 5 antibody
      • LPSAT antibody
      • Lyso-PC acyltransferase 3 antibody
      • Lyso-PC acyltransferase antibody
      • Lyso-PS acyltransferase antibody
      • Lysophosphatidylcholine acyltransferase 3 antibody
      • Lysophosphatidylcholine acyltransferase antibody
      • Lysophosphatidylserine acyltransferase antibody
      • Lysophospholipid acyltransferase 5 antibody
      • MBOA5 antibody
      • MBOA5_HUMAN antibody
      • Membrane-bound O-acyltransferase domain-containing protein 5 antibody
      • O-acyltransferase domain-containing protein 5 antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LPCAT3 antibody (ab223070)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LPCAT3 antibody (ab223070)

      Paraffin-embedded human liver tissue stained for LPCAT3 using ab223070 at 1/100 dilution in immunohistochemical analysis.

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LPCAT3 antibody (ab223070)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LPCAT3 antibody (ab223070)

      Paraffin-embedded human pancreatic tissue stained for LPCAT3 using ab223070 at 1/100 dilution in immunohistochemical analysis.

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab223070? Please let us know so that we can cite the reference in this datasheet.

    ab223070 has not yet been referenced specifically in any publications.

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