Key features and details
- Rabbit polyclonal to LPHN1 - N-terminal
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-LPHN1 antibody - N-terminal
DescriptionRabbit polyclonal to LPHN1 - N-terminal
SpecificityBLAST analysis of the peptide immunogen showed no homology with other Human proteins.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Rabbit, Hamster, Cow, Pig, Monkey, Gorilla, Opossum
Synthetic peptide, containing 16 amino acids, from the N-terminal extracellular region of Human LPHN1.
- Human brain (neurons and glia) tissue
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C.
Storage bufferPreservative: 0.1% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab140825 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 8 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
FunctionCalcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor propably implicated in the regulation of exocytosis.
Sequence similaritiesBelongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Contains 1 GPS domain.
Contains 1 olfactomedin-like domain.
Contains 1 SUEL-type lectin domain.
DomainThe extracellular domain coupled to the a single transmembrane region are sufficient for full responsiveness to alpha-latrotoxin.
modificationsAutoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus.
Cellular localizationCell membrane. Cell projection > axon. Cell projection > growth cone. Cell junction > synapse. Cell junction > synapse > presynaptic cell membrane. Cell junction > synapse > synaptosome. Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts.
- Information by UniProt
- Calcium independent alpha latrotoxin receptor 1 antibody
- Calcium-independent alpha-latrotoxin receptor 1 antibody
- CIRL-1 antibody
ab140825 has not yet been referenced specifically in any publications.