Overview

  • Product name

    Anti-LRIG1 antibody
  • Description

    Rabbit polyclonal to LRIG1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human LRIG1. (Near the C terminal; NP_056356).
    Database link: Q96JA1

  • Positive control

    • Human lung cancer tissue.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.3
    Preservative: 0.05% Sodium azide
    Constituents: 50% Glycerol, 49% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab197985 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.

Target

  • Function

    Act as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
  • Tissue specificity

    Widely expressed.
  • Sequence similarities

    Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
    Contains 15 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
  • Domain

    The LRRs and the Ig-domains are each sufficient for EGFR/ERBB1 binding. This interaction is abolished only when these two domains are deleted.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Leucine rich repeat protein antibody
    • Leucine rich repeat protein LRIG1 antibody
    • leucine rich repeats and immunoglobulin like domains 1 antibody
    • Leucine-rich repeats and immunoglobulin-like domains protein 1 antibody
    • leucine-rich repeats- and immunoglobulin-like domains-cotnaining protein 1 antibody
    • LIG 1 antibody
    • LIG-1 antibody
    • LIG1 antibody
    • Lrig1 antibody
    • LRIG1_HUMAN antibody
    • Ortholog of mouse integral membrane glycoprotein LIG 1 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue labeling LRIG1 with ab197985 at 1/120 dilution.

References

This product has been referenced in:

  • Yang B  et al. Lrig1 is a positive prognostic marker in hepatocellular carcinoma. Onco Targets Ther 9:7071-7079 (2016). IHC-P ; Human . Read more (PubMed: 27895499) »
See 1 Publication for this product

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