Validated using a knockout cell line

Anti-LRP1 antibody [EPR3724] (ab92544)

Publishing research using ab92544? Please let us know so that we can cite the reference in this datasheet.

ab92544 has been referenced in 53 publications.

  • Chen L  et al. PID1 in adipocytes modulates whole-body glucose homeostasis. Biochim Biophys Acta 1861:125-132 (2018). PubMed: 29391195
  • Chea C  et al. Molecular mechanism of inhibitory effects of bovine lactoferrin on the growth of oral squamous cell carcinoma. PLoS One 13:e0191683 (2018). PubMed: 29381751
  • Kitakaze T  et al. Lactoferrin promotes murine C2C12 myoblast proliferation and differentiation and myotube hypertrophy. Mol Med Rep 17:5912-5920 (2018). WB ; Mouse . PubMed: 29436684
  • Khan N  et al. Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation. J Neuroinflammation 15:91 (2018). WB . PubMed: 29558961
  • Guzman-Lepe J  et al. Liver-enriched transcription factor expression relates to chronic hepatic failure in humans. Hepatol Commun 2:582-594 (2018). PubMed: 29761173
  • Pan Y  et al. Cognitive benefits of lithium chloride in APP/PS1 mice are associated with enhanced brain clearance of ß-amyloid. Brain Behav Immun 70:36-47 (2018). WB ; Mouse . PubMed: 29545118
  • Li MS  et al. Differential expression of breast cancer-resistance protein, lung resistance protein, and multidrug resistance protein 1 in retinas of streptozotocin-induced diabetic mice. Int J Ophthalmol 10:515-523 (2017). WB, IHC-P . PubMed: 28503421
  • Cho CF  et al. Blood-brain-barrier spheroids as an in vitro screening platform for brain-penetrating agents. Nat Commun 8:15623 (2017). Human . PubMed: 28585535
  • McNally KE  et al. Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. Nat Cell Biol 19:1214-1225 (2017). WB . PubMed: 28892079
  • Acx H  et al. Inactivation of ?-secretases leads to accumulation of substrates and non-Alzheimer neurodegeneration. EMBO Mol Med 9:1088-1099 (2017). PubMed: 28588032
  • Wang L  et al. Effect of rosiglitazone on amyloid precursor protein processing and Aß clearance in streptozotocin-induced rat model of Alzheimer's disease. Iran J Basic Med Sci 20:474-480 (2017). WB ; Rat . PubMed: 28656081
  • Magnussen SN  et al. Cleavage of the urokinase receptor (uPAR) on oral cancer cells: regulation by transforming growth factor - ß1 (TGF-ß1) and potential effects on migration and invasion. BMC Cancer 17:350 (2017). PubMed: 28526008
  • Romagnuolo R  et al. Roles of the low density lipoprotein receptor and related receptors in inhibition of lipoprotein(a) internalization by proprotein convertase subtilisin/kexin type 9. PLoS One 12:e0180869 (2017). PubMed: 28750079
  • Flor AC  et al. A signature of enhanced lipid metabolism, lipid peroxidation and aldehyde stress in therapy-induced senescence. Cell Death Discov 3:17075 (2017). PubMed: 29090099
  • Lin JP  et al. LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair. Elife 6:N/A (2017). PubMed: 29251594
  • Rondón-Ortiz AN  et al. High Concentrations of Rosiglitazone Reduce mRNA and Protein Levels of LRP1 in HepG2 Cells. Front Pharmacol 8:772 (2017). PubMed: 29201005
  • Boyé K  et al. The role of CXCR3/LRP1 cross-talk in the invasion of primary brain tumors. Nat Commun 8:1571 (2017). PubMed: 29146996
  • Lu J  et al. Nano-enabled pancreas cancer immunotherapy using immunogenic cell death and reversing immunosuppression. Nat Commun 8:1811 (2017). PubMed: 29180759
  • Xiong H  et al. Yes-Associated Protein (YAP) Promotes Tumorigenesis in Melanoma Cells Through Stimulation of Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1). Sci Rep 7:15528 (2017). PubMed: 29138479
  • Mohamed LA  et al. Amylin Enhances Amyloid-ß Peptide Brain to Blood Efflux Across the Blood-Brain Barrier. J Alzheimers Dis 56:1087-1099 (2017). PubMed: 28059785
  • Rocchi A  et al. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. PLoS Genet 13:e1006962 (2017). PubMed: 28806762
  • Auderset L  et al. Low Density Lipoprotein-Receptor Related Protein 1 Is Differentially Expressed by Neuronal and Glial Populations in the Developing and Mature Mouse Central Nervous System. PLoS One 11:e0155878 (2016). WB, IHC . PubMed: 27280679
  • Vercellotti GM  et al. Hepatic Overexpression of Hemopexin Inhibits Inflammation and Vascular Stasis in Murine Models of Sickle Cell Disease. Mol Med 22:N/A (2016). PubMed: 27451971
  • Bian Z  et al. Cd47-Sirpa interaction and IL-10 constrain inflammation-induced macrophage phagocytosis of healthy self-cells. Proc Natl Acad Sci U S A 113:E5434-43 (2016). PubMed: 27578867
  • Chen Y  et al. HIV-1 Tat Regulates Occludin and Aß Transfer Receptor Expression in Brain Endothelial Cells via Rho/ROCK Signaling Pathway. Oxid Med Cell Longev 2016:4196572 (2016). PubMed: 27563375
  • Wang X  et al. Improvement of Electroacupuncture on APP/PS1 Transgenic Mice in Spatial Learning and Memory Probably due to Expression of Aß and LRP1 in Hippocampus. Evid Based Complement Alternat Med 2016:7603975 (2016). WB ; Mouse . PubMed: 27829865
  • Kim JA  et al. Presumed LRP1-targeting transport peptide delivers ß-secretase inhibitor to neurons in vitro with limited efficiency. Sci Rep 6:34297 (2016). PubMed: 27682851
  • Leca J  et al. Cancer-associated fibroblast-derived annexin A6+ extracellular vesicles support pancreatic cancer aggressiveness. J Clin Invest 126:4140-4156 (2016). WB, IP, IHC-P, ICC/IF ; Mouse, Human . PubMed: 27701147
  • Chuang TY  et al. LRP1 expression in microglia is protective during CNS autoimmunity. Acta Neuropathol Commun 4:68 (2016). ICC/IF ; Human . PubMed: 27400748
  • Guo YX  et al. 1,25-Dihydroxyvitamin D3 regulates expression of LRP1 and RAGE in vitro and in vivo, enhancing Aß1-40 brain-to-blood efflux and peripheral uptake transport. Neuroscience 322:28-38 (2016). WB ; Mouse . PubMed: 26820600
  • Gomes JR  et al. Transthyretin provides trophic support via megalin by promoting neurite outgrowth and neuroprotection in cerebral ischemia. Cell Death Differ 23:1749-1764 (2016). WB . PubMed: 27518433
  • Ikoma-Seki K  et al. Role of LRP1 and ERK and cAMP Signaling Pathways in Lactoferrin-Induced Lipolysis in Mature Rat Adipocytes. PLoS One 10:e0141378 (2015). WB . PubMed: 26506094
  • Yang E  et al. Lentivirus-induced knockdown of LRP1 induces osteoarthritic-like effects and increases susceptibility to apoptosis in chondrocytes via the nuclear factor-?B pathway. Exp Ther Med 10:97-105 (2015). PubMed: 26170918
  • van der Tuin SJ  et al. Anacetrapib reduces (V)LDL cholesterol by inhibition of CETP activity and reduction of plasma PCSK9. J Lipid Res 56:2085-93 (2015). PubMed: 26342106
  • Zhao Z  et al. Central role for PICALM in amyloid-ß blood-brain barrier transcytosis and clearance. Nat Neurosci 18:978-87 (2015). PubMed: 26005850
  • Alata W  et al. Human apolipoprotein E ?4 expression impairs cerebral vascularization and blood-brain barrier function in mice. J Cereb Blood Flow Metab 35:86-94 (2015). PubMed: 25335802
  • Samouillan V  et al. Cardiomyocyte intracellular cholesteryl ester accumulation promotes tropoelastin physical alteration and degradation: Role of LRP1 and cathepsin S. Int J Biochem Cell Biol 55:209-19 (2014). PubMed: 25218173
  • Kanai Y  et al. KIF13B enhances the endocytosis of LRP1 by recruiting LRP1 to caveolae. J Cell Biol 204:395-408 (2014). Mouse . PubMed: 24469637
  • Niesman IR  et al. Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. J Neuroinflammation 11:39 (2014). WB ; Mouse . PubMed: 24593993
  • Schorch B  et al. LRP1 is a receptor for Clostridium perfringens TpeL toxin indicating a two-receptor model of clostridial glycosylating toxins. Proc Natl Acad Sci U S A 111:6431-6 (2014). WB, ICC/IF ; Mouse . PubMed: 24737893
  • Hasegawa H  et al. The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-ß precursor. Nat Commun 5:3917 (2014). PubMed: 24894631
  • Yang J  et al. Recurrent LRP1-SNRNP25 and KCNMB4-CCND3 fusion genes promote tumor cell motility in human osteosarcoma. J Hematol Oncol 7:76 (2014). WB, IHC ; Human . PubMed: 25300797
  • Cal R  et al. Aggregated low-density lipoprotein induces LRP1 stabilization through E3 ubiquitin ligase CHFR downregulation in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 33:369-77 (2013). WB ; Human . PubMed: 23241409
  • Drevinge C  et al. Cholesteryl esters accumulate in the heart in a porcine model of ischemia and reperfusion. PLoS One 8:e61942 (2013). WB ; Pig . PubMed: 23637933
  • Messmer MN  et al. Identification of the cellular sentinels for native immunogenic heat shock proteins in vivo. J Immunol 191:4456-65 (2013). PubMed: 24048898
  • Kim HJ  et al. The hypolipidemic effect of cilostazol can be mediated by regulation of hepatic low-density lipoprotein receptor-related protein 1 (LRP1) expression. Metabolism N/A:N/A (2013). IHC ; Mouse, Human . PubMed: 24139096
  • Huang G  et al. Insulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilin. Mol Biol Cell 24:3115-22 (2013). WB . PubMed: 23966466
  • Yang W  et al. Aquaporin-4 mediates astrocyte response to ß-amyloid. Mol Cell Neurosci 49:406-414 (2012). WB ; Mouse . PubMed: 22365952
  • Hayashi H  et al. A potential neuroprotective role of apolipoprotein E-containing lipoproteins through low density lipoprotein receptor-related protein 1 in normal tension glaucoma. J Biol Chem 287:25395-406 (2012). WB, ICC/IF, IP ; Rat . PubMed: 22674573
  • Erickson MA  et al. Peripheral administration of antisense oligonucleotides targeting the amyloid-ß protein precursor reverses AßPP and LRP-1 overexpression in the aged SAMP8 mouse brain. J Alzheimers Dis 28:951-60 (2012). WB ; Mouse . PubMed: 22179572
  • Sarajärvi T  et al. Bepridil decreases Aß and calcium levels in the thalamus after middle cerebral artery occlusion in rats. J Cell Mol Med 16:2754-67 (2012). WB . PubMed: 22805236
  • Jiang R  et al. Apo- and holo-lactoferrin are both internalized by lactoferrin receptor via clathrin-mediated endocytosis but differentially affect ERK-signaling and cell proliferation in Caco-2 cells. J Cell Physiol 226:3022-31 (2011). WB ; Human . PubMed: 21935933
  • Kovac A  et al. Brain microvascular pericytes are immunoactive in culture: cytokine, chemokine, nitric oxide, and LRP-1 expression in response to lipopolysaccharide. J Neuroinflammation 8:139 (2011). WB ; Mouse . PubMed: 21995440


Sign up