Anti-Lrp2 / Megalin antibody (ab101011)
Key features and details
- Rabbit polyclonal to Lrp2 / Megalin
- Suitable for: ELISA, IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
-
Product name
Anti-Lrp2 / Megalin antibody
See all Lrp2 / Megalin primary antibodies -
Description
Rabbit polyclonal to Lrp2 / Megalin -
Host species
Rabbit -
Tested applications
Suitable for: ELISA, IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat -
Immunogen
Synthetic peptides derived from the C terminal part of Human Lrp2/ Megalin.
-
General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Constituent: Whole serum -
Concentration information loading...
-
Purity
Whole antiserum -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab101011 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
ELISA |
Use at an assay dependent concentration.
|
|
IHC-P |
Use at an assay dependent concentration.
|
Notes |
---|
ELISA
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
Target
-
Function
Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid-hormone and para-thyroid-hormone-related protein release. -
Tissue specificity
Absorptive epithelia, including renal proximal tubules. -
Involvement in disease
Defects in LRP2 are the cause of Donnai-Barrow syndrome (DBS) [MIM:222448]; also known as faciooculoacousticorenal syndrome (FOAR syndrome). DBS is a rare autosomal recessive disorder characterized by major malformations including agenesis of the corpus callosum, congenital diaphragmatic hernia, facial dysmorphology, ocular anomalies, sensorineural hearing loss and developmental delay. The FOAR syndrome was first described as comprising facial anomalies, ocular anomalies, sensorineural hearing loss, and proteinuria. DBS and FOAR were first described as distinct disorders but the classic distinguishing features between the 2 disorders were presence of proteinuria and absence of diaphragmatic hernia and corpus callosum anomalies in FOAR. Early reports noted that the 2 disorders shared many phenotypic features and may be identical. Although there is variability in the expression of some features (e.g. agenesis of the corpus callosum and proteinuria), DBS and FOAR are now considered to represent the same entity. -
Sequence similarities
Belongs to the LDLR family.
Contains 17 EGF-like domains.
Contains 36 LDL-receptor class A domains.
Contains 37 LDL-receptor class B repeats. -
Cellular localization
Membrane. Membrane > coated pit. - Information by UniProt
-
Database links
- Entrez Gene: 4036 Human
- Entrez Gene: 14725 Mouse
- Entrez Gene: 29216 Rat
- Omim: 600073 Human
- SwissProt: P98164 Human
- SwissProt: A2ARV4 Mouse
- SwissProt: P98158 Rat
- Unigene: 657729 Human
see all -
Alternative names
- Calcium sensor protein antibody
- DBS antibody
- Glycoprotein 330 antibody
see all
Datasheets and documents
-
Datasheet download
References (1)
ab101011 has been referenced in 1 publication.
- Baines RJ et al. CD36 mediates proximal tubular binding and uptake of albumin and is upregulated in proteinuric nephropathies. Am J Physiol Renal Physiol 303:F1006-14 (2012). PubMed: 22791331