Anti-LRP5 + LRP6 antibody (ab217700)
Key features and details
- Rabbit polyclonal to LRP5 + LRP6
- Suitable for: IHC-P
- Reacts with: Mouse, Rat
- Isotype: IgG
Overview
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Product name
Anti-LRP5 + LRP6 antibody -
Description
Rabbit polyclonal to LRP5 + LRP6 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Rat
Predicted to work with: Human
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Immunogen
Synthetic peptide within Human LRP5 + LRP6 aa 480-530 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
Database link: O75581 -
Positive control
- IHC-P: Mouse embryo and rat brain tissue.
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General notes
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.09% Sodium azide
Constituents: 1% BSA, 50% Glycerol -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab217700 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | 1/100 - 1/500. |
Target
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Relevance
LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization. -
Cellular localization
Membrane; single-pass type I membrane protein -
Database links
- Entrez Gene: 4040 Human
- Entrez Gene: 4041 Human
- Entrez Gene: 16973 Mouse
- Entrez Gene: 16974 Mouse
- Omim: 603506 Human
- Omim: 603507 Human
- SwissProt: O75197 Human
- SwissProt: O75581 Human
see all -
Alternative names
- BMND1 antibody
- EVR 4 antibody
- EVR1 antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRP5 + LRP6 antibody (ab217700)
Immunohistochemical analysis of formalin-fixed paraffin-embedded sections of rat brain tissue labeling LRP5 + LRP6 with ab217700 at a 1/200 dilution, followed by conjugation to a secondary antibody and DAB staining.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRP5 + LRP6 antibody (ab217700)Immunohistochemical analysis of formalin-fixed paraffin-embedded sections of mouse embryo tissue labeling LRP5 + LRP6 with ab217700 at a 1/200 dilution, followed by conjugation to a secondary antibody and DAB staining.
Datasheets and documents
References (0)
ab217700 has not yet been referenced specifically in any publications.
