Anti-LRP5 + LRP6 antibody (ab217700)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-LRP5 + LRP6 antibody -
Description
Rabbit polyclonal to LRP5 + LRP6 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Mouse, Rat
Predicted to work with: Human
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Immunogen
Synthetic peptide within Human LRP5 + LRP6 aa 480-530 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
Database link: O75581 -
Positive control
- IHC-P: Mouse embryo and rat brain tissue.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.09% Sodium azide
Constituents: 1% BSA, 50% Glycerol -
Concentration information loading... -
Purity
Protein A purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab217700 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | 1/100 - 1/500. |
Target
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Relevance
LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization. -
Cellular localization
Membrane; single-pass type I membrane protein -
Database links
- Entrez Gene: 4040 Human
- Entrez Gene: 4041 Human
- Entrez Gene: 16973 Mouse
- Entrez Gene: 16974 Mouse
- Omim: 603506 Human
- Omim: 603507 Human
- SwissProt: O75197 Human
- SwissProt: O75581 Human
see all -
Alternative names
- BMND1 antibody
- EVR 4 antibody
- EVR1 antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRP5 + LRP6 antibody (ab217700)Immunohistochemical analysis of formalin-fixed paraffin-embedded sections of rat brain tissue labeling LRP5 + LRP6 with ab217700 at a 1/200 dilution, followed by conjugation to a secondary antibody and DAB staining.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LRP5 + LRP6 antibody (ab217700)Immunohistochemical analysis of formalin-fixed paraffin-embedded sections of mouse embryo tissue labeling LRP5 + LRP6 with ab217700 at a 1/200 dilution, followed by conjugation to a secondary antibody and DAB staining.
Protocols
Datasheets and documents
References
ab217700 has not yet been referenced specifically in any publications.
