Product nameAnti-LRP5 + LRP6 antibody
See all LRP5 + LRP6 primary antibodies
DescriptionRabbit polyclonal to LRP5 + LRP6
SpecificityThe antibody recognizes the ~170 kDa full length LRP-5/6. A cleavage fragment (~120 kDa) can also be detected.
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Mouse, Human
Synthetic peptide surrounding amino acid 437 of LRP (Human)
- Jurkat cell lysate
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: 0.01% Thimerosal (merthiolate)
Constituents: PBS, 0.5% BSA, 30% Glycerol
Concentration information loading...
PurityProtein A purified
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Cholesterol Metabolism
Our Abpromise guarantee covers the use of ab51910 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.5 - 4 µg/ml. Predicted molecular weight: 179 kDa.|
RelevanceLDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
Cellular localizationMembrane; single-pass type I membrane protein
- BMND1 antibody
- EVR 4 antibody
- EVR1 antibody
All lanes : Anti-LRP5 + LRP6 antibody (ab51910) at 4 µg/ml
Lane 1 : Jurkat cell lysate at 100 µg
Lane 2 : Jurkat cell lysate at 50 µg
All lanes : HRP conjugated goat anti rabbit IgG
Predicted band size: 179 kDa
Observed band size: 190 kDa why is the actual band size different from the predicted?
ab51910 has not yet been referenced specifically in any publications.