Overview

  • Product name
  • Description
    Rabbit polyclonal to LRP5 + LRP6
  • Host species
    Rabbit
  • Specificity
    The antibody recognizes the ~170 kDa full length LRP-5/6. A cleavage fragment (~120 kDa) can also be detected.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Synthetic peptide surrounding amino acid 437 of LRP (Human)

  • Positive control
    • Jurkat cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab51910 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 4 µg/ml. Predicted molecular weight: 179 kDa.

Target

  • Relevance
    LDL related proteins, LRP 5 and LRP 6, are members of the LDL receptor superfamily, which were found to be involved in the canonical Wnt signaling pathway. Mammalian LRP 6 was shown to bind to Wnt 1 and enhance Wnt-induced developmental processes in Xenopus embryos. Mice lacking LRP 6 exhibited developmental defects that are similar to those caused by deficiencies in various Wnt proteins. Recent work also shows that Wnt proteins induce the binding of LRP 5 to Axin, leading Axin degradation and beta catenin stabilization.
  • Cellular localization
    Membrane; single-pass type I membrane protein
  • Database links
  • Alternative names
    • BMND1 antibody
    • EVR 4 antibody
    • EVR1 antibody
    • EVR4 antibody
    • HBM antibody
    • Low density lipoprotein receptor related protein 5 antibody
    • Low density lipoprotein receptor related protein 6 antibody
    • LR3 antibody
    • LRP7 antibody
    • OPPG antibody
    • OPS antibody
    • OPTA1 antibody
    • VBCH2 antibody
    see all

Images

  • All lanes : Anti-LRP5 + LRP6 antibody (ab51910) at 4 µg/ml

    Lane 1 : Jurkat cell lysate at 100 µg
    Lane 2 : Jurkat cell lysate at 50 µg

    Secondary
    All lanes : HRP conjugated goat anti rabbit IgG

    Predicted band size: 179 kDa
    Observed band size: 190 kDa
    why is the actual band size different from the predicted?

References

ab51910 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Question
Answer


I am very pleased to hear you would like to accept our offer and test ab51910 in IHC-Fr. This code will give you ab51910 off your next order before the expiration date. To redeem this offer, please submit an Abreview for IHC-Fr and include this code in the “Additional Comments” section so we know the Abreview is for this promotion. Please remember that submission of the Abreview is sufficient for the discount code to become active.
For more information on how to submit an Abreview, please visit the site: www.abcam.com/Abreviews.
Remember, we publish both positive and negative Abreviews on our datasheets so please submit the results of your tests. The code will be active once the Abreview has been submitted and can be redeemed in one of the following ways: 1) Call to place your order and mention the code to our customer service department; 2) Include the code in your fax order; 3) Place your order on the web and enter the promotional code.
Any feedback that you can provide will be greatly appreciated, whether positive or negative. If you have any further questions, please do not hesitate to contact us. We look forward to receiving your Abreview and wish you luck with your research.
The terms and conditions applicable to this offer can be found here: www.abcam.com/abtrial.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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