Overview

  • Product name

  • Description

    Rabbit polyclonal to LRSAM1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Mouse
    Predicted to work with: Cow, Human
  • Immunogen

    Recombinant fragment within Human LRSAM1 (internal sequence). The exact sequence is proprietary.
    Database link: Q6UWE0

  • Positive control

    • WB: Mouse spinal cord extract.

Properties

Applications

Our Abpromise guarantee covers the use of ab229211 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 84 kDa.

Target

  • Function

    E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos.
  • Tissue specificity

    Highly expressed in adult spinal cord motoneurons as well as in fetal spinal cord and muscle tissue.
  • Pathway

    Protein modification; protein ubiquitination.
  • Involvement in disease

    Charcot-Marie-Tooth disease 2P (CMT2P) [MIM:614436]: An axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similarities

    Contains 6 LRR (leucine-rich) repeats.
    Contains 1 RING-type zinc finger.
    Contains 1 SAM (sterile alpha motif) domain.
  • Domain

    The coiled coil domains interact with the SB domain of TSG101.
    The PTAP motifs mediate the binding to UEV domains.
  • Cellular localization

    Cytoplasm. Displays a punctuate distribution and localizes to a submembranal ring.
  • Information by UniProt
  • Database links

  • Alternative names

    • CMT2P antibody
    • E3 ubiquitin protein ligase LRSAM1 antibody
    • E3 ubiquitin-protein ligase LRSAM1 antibody
    • EC 6.3.2.- antibody
    • FLJ31641 antibody
    • hTAL antibody
    • Leucine rich repeat and sterile alpha motif containing 1 antibody
    • Leucine rich repeat and sterile alpha motif containing protein 1 antibody
    • Leucine-rich repeat and sterile alpha motif-containing protein 1 antibody
    • LRSAM1 antibody
    • LRSM1_HUMAN antibody
    • OTTHUMP00000022174 antibody
    • OTTHUMP00000022175 antibody
    • RIFLE antibody
    • TAL antibody
    • Tsg101 associated ligase antibody
    • Tsg101-associated ligase antibody
    see all

Images

  • Anti-LRSAM1 antibody (ab229211) at 1/2000 dilution + Mouse spinal cord extract at 50 µg

    Predicted band size: 84 kDa



    7.5% SDS-PAGE gel.

References

ab229211 has not yet been referenced specifically in any publications.

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