Anti-LSD2 / AOF1 antibody (ab234863)
- Datasheet
- References
- Protocols
Overview
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Product name
Anti-LSD2 / AOF1 antibody
See all LSD2 / AOF1 primary antibodies -
Description
Rabbit polyclonal to LSD2 / AOF1 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant fragment corresponding to Human LSD2/ AOF1 aa 451-544.
Database link: Q8NB78 -
Positive control
- IHC-P: Human liver and kidney tissues.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.03% Proclin
Constituents: 50% Glycerol, PBS -
Concentration information loading... -
Purity
Protein G purified -
Purification notes
Purity >95%. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab234863 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | 1/20 - 1/200. |
Target
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Function
Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. -
Sequence similarities
Belongs to the flavin monoamine oxidase family.
Contains 1 CW-type zinc finger.
Contains 1 SWIRM domain. -
Domain
The SWIRM domain may act as an anchor site for a histone tail. -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 221656 Human
- Omim: 613081 Human
- SwissProt: Q8NB78 Human
- Unigene: 709336 Human
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Form
There are 3 isoforms produced by alternative splicing. -
Alternative names
- amine oxidase (flavin containing) domain 1 antibody
- amine oxidase, flavin containing 1 antibody
- AOF1 antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LSD2 / AOF1 antibody (ab234863)Paraffin-embedded human liver tissue stained for LSD2 / AOF1 using ab234863 at 1/100 dilution in immunohistochemical analysis.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LSD2 / AOF1 antibody (ab234863)Paraffin-embedded human kidney tissue stained for LSD2 / AOF1 using ab234863 at 1/100 dilution in immunohistochemical analysis.
References
ab234863 has not yet been referenced specifically in any publications.
