Overview

  • Product name

  • Description

    Rabbit polyclonal to LTA
  • Host species

    Rabbit
  • Specificity

    ab106353 does not react with other proteins
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Recombinant fragment
    Predicted to work with: Mouse, Rat, Dog, Human
  • Immunogen

    Synthetic peptide corresponding to Human LTA aa 73-88 (internal sequence).
    Sequence:

    KQNSLLWRANTDRAFL

  • Positive control

    • Recombinant Human LTA protein
  • General notes

     This product was previously labelled as TNF beta

     

Properties

Applications

Our Abpromise guarantee covers the use of ab106353 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 22 kDa.

Target

  • Function

    Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
  • Involvement in disease

    Genetic variations in LTA are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
  • Sequence similarities

    Belongs to the tumor necrosis factor family.
  • Cellular localization

    Secreted. Membrane. The homotrimer is secreted. The heterotrimer is membrane-associated.
  • Information by UniProt
  • Database links

  • Alternative names

    • LTalpha antibody
    • DAMA-25N12.13-004 antibody
    • DIF antibody
    • LT alpha antibody
    • LT antibody
    • LT-alpha antibody
    • Lta antibody
    • Lymphotoxin alpha (TNF superfamily, member 1) antibody
    • Lymphotoxin alpha antibody
    • Lymphotoxin-alpha antibody
    • MGC117668 antibody
    • OTTHUMP00000037612 antibody
    • OTTHUMP00000037613 antibody
    • TNF B antibody
    • TNF superfamily member 1 antibody
    • TNF, lymphocyte-derived antibody
    • TNF-beta antibody
    • TNFB antibody
    • TNFB_HUMAN antibody
    • TNFbeta antibody
    • TNFSF 1 antibody
    • TNFSF1 antibody
    • TNLG1E antibody
    • Tumor necrosis factor beta antibody
    • tumor necrosis factor ligand 1E antibody
    • Tumor necrosis factor ligand superfamily member 1 antibody
    • tumor necrosis factor superfamily member 1 antibody
    see all

Images

  • All lanes : Anti-LTA antibody (ab106353) at 1 µg/ml

    Lane 1 : Recombinant Human LTA protein at 20ng
    Lane 2 : Recombinant Human LTA protein at 5ng
    Lane 3 : Recombinant Human LTA protein at 2.5ng

    Predicted band size: 22 kDa

References

This product has been referenced in:

  • Sun XH  et al. miR-155 mediates inflammatory injury of hippocampal neuronal cells via the activation of microglia. Mol Med Rep 19:2627-2635 (2019). Read more (PubMed: 30720115) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab106353.
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