Anti-LTBP2 antibody (ab121193)
- Datasheet
- References (6)
- Protocols
Overview
-
Product name
Anti-LTBP2 antibody
See all LTBP2 primary antibodies -
Description
Rabbit polyclonal to LTBP2 -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
antigen sequence, corresponding to internal sequence amino acids 241-376 of Human LTBP2.
-
Positive control
- Human prostate tissue.
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.02% Sodium azide
Constituents: 59% PBS, 40% Glycerol -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
-
Compatible Secondaries
-
Isotype control
-
Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab121193 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | 1/800. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
Target
-
Function
May play an integral structural role in elastic-fiber architectural organization and/or assembly. -
Tissue specificity
Expressed in lung, weakly expressed in heart, placenta, liver and skeletal muscle. -
Involvement in disease
Defects in LTBP2 are the cause of primary congenital glaucoma type 3D (GLC3D) [MIM:613086]. An autosomal recessive form of primary congenital glaucoma (PCG). PCG is characterized by marked increase of intraocular pressure at birth or early childhood, large ocular globes (buphthalmos) and corneal edema. It results from developmental defects of the trabecular meshwork and anterior chamber angle of the eye that prevent adequate drainage of aqueous humor.
Defects in LTBP2 are the cause of microspherophakia (MCSPH) [MIM:251750]. It is a rare disease characterized by smaller and more spherical lenses than normal bilaterally, an increased anteroposterior thickness of the lens and highly myopic eyes. Lens dislocation or subluxation may occur, leading to defective accommodation. -
Sequence similarities
Belongs to the LTBP family.
Contains 20 EGF-like domains.
Contains 4 TB (TGF-beta binding) domains. -
Domain
Associates covalently with small latent TGF-beta complex via Repeat B and Repeat C. -
Post-translational
modificationsContains hydroxylated asparagine residues. -
Cellular localization
Secreted. Localized in nuchal ligament and aorta to the fibrillin-containing, microfibrillar component of elastic fibers. - Information by UniProt
-
Database links
- Entrez Gene: 4053 Human
- Omim: 602091 Human
- SwissProt: Q14767 Human
- Unigene: 512776 Human
- Unigene: 597522 Human
-
Alternative names
- C14orf141 antibody
- Chromosome 14 open reading frame 141 antibody
- Latent TGF beta binding protein 2 antibody
see all
Images
-
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LTBP2 antibody (ab121193)ab121193 at 1/800 dilution staining LTBP2 in Paraffin-embedded Human Prostate tissue by Immunohistochemistry.
Protocols
Datasheets and documents
References
This product has been referenced in:
- Huang Y et al. High Expression of LTBP2 Contributes to Poor Prognosis in Colorectal Cancer Patients and Correlates with the Mesenchymal Colorectal Cancer Subtype. Dis Markers 2019:5231269 (2019). Read more (PubMed: 30956730) »
- Wang J et al. LTBP2 promotes the migration and invasion of gastric cancer cells and predicts poor outcome of patients with gastric cancer. Int J Oncol 52:1886-1898 (2018). Read more (PubMed: 29620158) »
