Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha (ab141759)

Overview

  • Product name

    Luffariellolide, phospholipase A2 (PLA2) inhibitor. Agonist at RARalpha
  • Description

    Potent phospholipase A2 (PLA2) inhibitor. Agonist at RARα
  • Biological description

    Potent, partially reversible phospholipase A2 (PLA2) inhibitor (IC50 = 5 µM). Also a novel RARα agonist (EC50 = 1 μM). Derivative of marine sponge Luffariella sp. Displays anti-inflammatory activity and active in vivo.
  • Purity

    > 98%
  • CAS Number

    111149-87-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Wang S  et al. Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells. Biochem J 446:79-87 (2012). Read more (PubMed: 22642567) »
  • Glaser KB  et al. Cellular and topical in vivo inflammatory murine models in the evaluation of inhibitors of phospholipase A2. Skin Pharmacol 8:300-8 (1995). Read more (PubMed: 8688196) »
  • Glaser KB  et al. PAF and LTB4 biosynthesis in the human neutrophil: effects of putative inhibitors of phospholipase A2 and specific inhibitors of 5-lipoxygenase. Agents Actions 34:89-92 (1991). Read more (PubMed: 1665306) »

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