Overview

  • Product name

    Anti-Lunatic Fringe antibody
    See all Lunatic Fringe primary antibodies
  • Description

    Rabbit polyclonal to Lunatic Fringe
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human Lunatic Fringe aa 1-250.
    Database link: Q8NES3

  • Positive control

    • IHC-P: Human testis tissue and adrenal gland tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab235534 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning.
  • Involvement in disease

    Defects in LFNG are the cause of spondylocostal dysostosis type 3 (SCDO3) [MIM:609813]. An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
  • Sequence similarities

    Belongs to the glycosyltransferase 31 family.
  • Post-translational
    modifications

    A soluble form may be derived from the membrane form by proteolytic processing.
  • Cellular localization

    Golgi apparatus membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 3-N-acetylglucosaminyltransferase lunatic fringe antibody
    • Beta-1 antibody
    • Beta-13-N-acetylglucosaminyltransferase lunatic fringe antibody
    • lfng antibody
    • LFNG_HUMAN antibody
    • O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase antibody
    • SCDO3 antibody
    see all

Images

  • Paraffin-embedded human adrenal gland tissue stained for Lunatic Fringe using ab235534 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human testis tissue stained for Lunatic Fringe using ab235534 at 1/100 dilution in immunohistochemical analysis.

References

ab235534 has not yet been referenced specifically in any publications.

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