Key features and details
- Rabbit polyclonal to Lunatic Fringe
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Lunatic Fringe antibody
See all Lunatic Fringe primary antibodies
DescriptionRabbit polyclonal to Lunatic Fringe
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Recombinant fragment corresponding to Human Lunatic Fringe aa 1-250.
Database link: Q8NES3
- IHC-P: Human testis tissue and adrenal gland tissue.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab235534 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/20 - 1/200.|
FunctionGlycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning.
Involvement in diseaseDefects in LFNG are the cause of spondylocostal dysostosis type 3 (SCDO3) [MIM:609813]. An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
Sequence similaritiesBelongs to the glycosyltransferase 31 family.
modificationsA soluble form may be derived from the membrane form by proteolytic processing.
Cellular localizationGolgi apparatus membrane.
- Information by UniProt
- 3-N-acetylglucosaminyltransferase lunatic fringe antibody
- Beta-1 antibody
- Beta-13-N-acetylglucosaminyltransferase lunatic fringe antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab235534 has not yet been referenced specifically in any publications.