Recombinant
RabMAb

Recombinant Anti-Lunatic Fringe antibody [EPR10391(B)] - BSA and Azide free (ab249022)

Overview

  • Product name

    Anti-Lunatic Fringe antibody [EPR10391(B)] - BSA and Azide free
    See all Lunatic Fringe primary antibodies
  • Description

    Rabbit monoclonal [EPR10391(B)] to Lunatic Fringe - BSA and Azide free
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, Flow Cytmore details
    Unsuitable for: ICC,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human Lunatic Fringe. The exact sequence is proprietary.
    Database link: Q8NES3

  • General notes

    Ab249022 is the carrier-free version of ab151699. This format is designed for use in antibody labeling, including fluorochromes, metal isotopes, oligonucleotides, enzymes.

     

    Our carrier-free formats are supplied in a buffer free of BSA, sodium azide and glycerol for higher conjugation efficiency.

    Use our conjugation kits  for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

    ab249022 is compatible with the Maxpar® Antibody Labeling Kit from Fluidigm.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.

Properties

Applications

Our Abpromise guarantee covers the use of ab249022 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 42 kDa.
Flow Cyt Use at an assay dependent concentration.
  • Application notes
    Is unsuitable for ICC,IHC-P or IP.
  • Target

    • Function

      Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Decreases the binding of JAGGED1 to NOTCH2 but not that of DELTA1. Essential mediator of somite segmentation and patterning.
    • Involvement in disease

      Defects in LFNG are the cause of spondylocostal dysostosis type 3 (SCDO3) [MIM:609813]. An autosomal recessive condition of variable severity associated with vertebral and rib segmentation defects. The main skeletal malformations include fusion of vertebrae, hemivertebrae, fusion of certain ribs, and other rib malformations. Deformity of the chest and spine (severe scoliosis, kyphoscoliosis and lordosis) is a natural consequence of the malformation and leads to a dwarf-like appearance. As the thorax is small, infants frequently have respiratory insufficiency and repeated respiratory infections resulting in life-threatening complications in the first year of life.
    • Sequence similarities

      Belongs to the glycosyltransferase 31 family.
    • Post-translational
      modifications

      A soluble form may be derived from the membrane form by proteolytic processing.
    • Cellular localization

      Golgi apparatus membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • 3-N-acetylglucosaminyltransferase lunatic fringe antibody
      • Beta-1 antibody
      • Beta-13-N-acetylglucosaminyltransferase lunatic fringe antibody
      • lfng antibody
      • LFNG_HUMAN antibody
      • O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase antibody
      • SCDO3 antibody
      see all

    References

    ab249022 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

    There are currently no Customer reviews or Questions for ab249022.
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    Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
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