Luzindole (N-0774), melatonin receptor antagonist (ab145232)

Overview

  • Product name

    Luzindole (N-0774), melatonin receptor antagonist
  • Description

    Competitive melatonin receptor antagonist
  • Alternative names

    • N-0774
  • Biological description

    Competitive melatonin receptor antagonist (IC50 = 1 μM). Shows selectivity towards melatonin 1B (Ki values are 45 and 603 nM for MEL-1B and MEL-1A respectively). Inhibits melatonin-induced pigment aggregation (IC50 = 2.1 μM) and shows neuroprotective effects in vivo.
  • Purity

    > 96%
  • CAS Number

    117946-91-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Drobnik J  et al. Melatonin-induced augmentation of collagen deposition in cultures of fibroblasts and myofibroblasts is blocked by luzindole--a melatonin membrane receptors inhibitor. Pharmacol Rep 65:642-9 (2013). Read more (PubMed: 23950586) »
  • Sugawara T  et al. The melatonin antagonist luzindole protects retinal photoreceptors from light damage in the rat. Invest Ophthalmol Vis Sci 39:2458-65 (1998). Read more (PubMed: 9804154) »
  • Dubocovich ML Luzindole (N-0774): a novel melatonin receptor antagonist. J Pharmacol Exp Ther 246:902-10 (1988). Read more (PubMed: 2843633) »

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