Recombinant
RabMAb

Anti-LXR alpha antibody [EPR6508(N)] - BSA and Azide free (ab190727)

Overview

  • Product name
    Anti-LXR alpha antibody [EPR6508(N)] - BSA and Azide free
    See all LXR alpha primary antibodies
  • Description
    Rabbit monoclonal [EPR6508(N)] to LXR alpha - BSA and Azide free
  • Host species
    Rabbit
  • Tested applications
    Suitable for: Flow Cyt, WB, ICC/IFmore details
    Unsuitable for: IHC-P or IP
  • Species reactivity
    Reacts with: Mouse, Rat, Sheep, Human
  • Immunogen

    Synthetic peptide within Human LXR alpha aa 50-150 (Cysteine residue). The exact sequence is proprietary.
    Database link: Q13133

  • Positive control
    • Human fetal liver, Jurkat and MCF-7 cell lysates. Jurkat cells and MCF7 cells.
  • General notes

    Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with <1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Applications

Our Abpromise guarantee covers the use of ab190727 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use at an assay dependent concentration.

ab199376 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.

WB Use at an assay dependent concentration. Predicted molecular weight: 50 kDa.

Can be blocked with LXR alpha peptide (ab191835).

ICC/IF Use at an assay dependent concentration.
  • Application notes
    Is unsuitable for IHC-P or IP.
  • Target

    • Function
      Orphan receptor. Interaction with RXR shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8.
    • Tissue specificity
      Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals.
    • Sequence similarities
      Belongs to the nuclear hormone receptor family. NR1 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • Liver X receptor alpha antibody
      • LXR a antibody
      • LXRA antibody
      • NR1H3 antibody
      • NR1H3_HUMAN antibody
      • Nuclear receptor subfamily 1 group H member 3 antibody
      • Oxysterols receptor LXR alpha antibody
      • Oxysterols receptor LXR-alpha antibody
      • RLD 1 antibody
      • RLD1 antibody
      see all

    References

    ab190727 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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