Anti-LXR alpha antibody [PPZ0412] - ChIP Grade (ab41902)

Mouse monoclonal LXR alpha antibody [PPZ0412]. Validated in WB, IP, ELISA, IHC, Flow Cyt, ChIP, ICC/IF and tested in Mouse, Rat, Human. Cited in 38 publication(s). Independently reviewed in 11 review(s).

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ab41902 has been referenced in 41 publications.

  • Gao Y  et al. LXRa Promotes the Differentiation of Human Gastric Cancer Cells through Inactivation of Wnt/ß-catenin Signaling. J Cancer 10:156-167 (2019). PubMed: 30662536
  • Becares N  et al. Impaired LXRa Phosphorylation Attenuates Progression of Fatty Liver Disease. Cell Rep 26:984-995.e6 (2019). PubMed: 30673619
  • Moreno-Santos I  et al. The Antagonist Effect of Arachidonic Acid on GLUT4 Gene Expression by Nuclear Receptor Type II Regulation. Int J Mol Sci 20:N/A (2019). PubMed: 30813326
  • El Kasmi KC  et al. Macrophage-derived IL-1ß/NF-?B signaling mediates parenteral nutrition-associated cholestasis. Nat Commun 9:1393 (2018). PubMed: 29643332
  • Feng T  et al. SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression. Atherosclerosis 274:172-181 (2018). PubMed: 29787963
  • Zhang G  et al. Placental mechanism of prenatal nicotine exposure-reduced blood cholesterol levels in female fetal rats. Toxicol Lett 296:31-38 (2018). PubMed: 30036686
  • Jeong SJ  et al. Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux. Autophagy 14:120-133 (2018). PubMed: 28605287
  • Bellomo C  et al. Snail mediates crosstalk between TGFß and LXRa in hepatocellular carcinoma. Cell Death Differ 25:885-903 (2018). PubMed: 29230000
  • Zhao XY  et al. Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. Nat Commun 9:2986 (2018). PubMed: 30061575
  • Kim H The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophages. Sci Rep 7:7591 (2017). PubMed: 28790455
  • Xian X  et al. LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis. Elife 6:N/A (2017). PubMed: 29144234
  • Nikolova V  et al. Changes in LXR signaling influence early-pregnancy lipogenesis and protect against dysregulated fetoplacental lipid homeostasis. Am J Physiol Endocrinol Metab 313:E463-E472 (2017). PubMed: 28420650
  • Song L  et al. Phytosterol esters attenuate hepatic steatosis in rats with non-alcoholic fatty liver disease rats fed a high-fat diet. Sci Rep 7:41604 (2017). WB ; Rat . PubMed: 28169366
  • Ikhlef S  et al. Human paraoxonase 1 overexpression in mice stimulates HDL cholesterol efflux and reverse cholesterol transport. PLoS One 12:e0173385 (2017). WB ; Mouse . PubMed: 28278274
  • Stein S  et al. Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease. J Clin Invest 127:583-592 (2017). PubMed: 28094767
  • Shrestha E  et al. Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages. J Biol Chem 291:11172-84 (2016). PubMed: 27026705
  • Sharma M  et al. Chemotherapy Agents Alter Plasma Lipids in Breast Cancer Patients and Show Differential Effects on Lipid Metabolism Genes in Liver Cells. PLoS One 11:e0148049 (2016). WB . PubMed: 26807857
  • Kim SY  et al. Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages. Sci Rep 6:29673 (2016). Mouse . PubMed: 27406916
  • Moreno M  et al. 3,5,3'-Triiodo-L-Thyronine- and 3,5-Diiodo-L-Thyronine- Affected Metabolic Pathways in Liver of LDL Receptor Deficient Mice. Front Physiol 7:545 (2016). WB ; Mouse . PubMed: 27909409
  • Bouttier M  et al. Alu repeats as transcriptional regulatory platforms in macrophage responses to M. tuberculosis infection. Nucleic Acids Res N/A:N/A (2016). Human . PubMed: 27604870
  • Sun X  et al. Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation. J Biol Chem 291:1115-22 (2016). WB . PubMed: 26511317
  • Zhao Y  et al. YiXin-Shu, a ShengMai-San-based traditional Chinese medicine formula, attenuates myocardial ischemia/reperfusion injury by suppressing mitochondrial mediated apoptosis and upregulating liver-X-receptor a. Sci Rep 6:23025 (2016). WB ; Mouse . PubMed: 26964694
  • Popineau L  et al. Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance. Mol Cell Biol 36:2168-81 (2016). WB ; Mouse . PubMed: 27215388
  • Dang F  et al. Fasting and Feeding Signals Control the Oscillatory Expression of Angptl8 to Modulate Lipid Metabolism. Sci Rep 6:36926 (2016). WB . PubMed: 27845381
  • Gabitova L  et al. Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR. Cell Rep 12:1927-38 (2015). PubMed: 26344763
  • Hussein MA  et al. LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2. PLoS One 10:e0135218 (2015). WB, ChIP . PubMed: 26288135
  • Xu Y  et al. Rutaecarpine suppresses atherosclerosis in ApoE-/- mice through upregulating ABCA1 and SR-BI within RCT. J Lipid Res 55:1634-47 (2014). PubMed: 24908654
  • Vinod M  et al. miR-206 controls LXRa expression and promotes LXR-mediated cholesterol efflux in macrophages. Biochim Biophys Acta 1841:827-35 (2014). WB ; Mouse, Human . PubMed: 24603323
  • Liang B  et al. Angiotensin-(1-7) upregulates expression of ABCA1 and ABCG1 through the Mas receptor via the liver X receptor alpha signaling pathway in THP-1 macrophages treated with Angiotensin II. Clin Exp Pharmacol Physiol N/A:N/A (2014). Human . PubMed: 25225013
  • He Q  et al. Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice. Cardiovasc Diabetol 13:149 (2014). Mouse . PubMed: 25416469
  • Zhao J  et al. Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway. J Biol Chem 289:11282-92 (2014). WB ; Human . PubMed: 24599963
  • A-Gonzalez N  et al. The nuclear receptor LXRa controls the functional specialization of splenic macrophages. Nat Immunol 14:831-9 (2013). WB ; Mouse . PubMed: 23770640
  • Feldmann R  et al. Genome-wide analysis of LXRa activation reveals new transcriptional networks in human atherosclerotic foam cells. Nucleic Acids Res 41:3518-31 (2013). WB, ChIP ; Human . PubMed: 23393188
  • Khan OM  et al. Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice. Circulation 127:782-90 (2013). Mouse . PubMed: 23334894
  • Asquith DL  et al. The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release. Ann Rheum Dis N/A:N/A (2013). WB ; Human . PubMed: 23434566
  • Canavan M  et al. Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-?Bp50. Innate Immun N/A:N/A (2013). PubMed: 24045337
  • Feldmann R  et al. Foam cell specific LXRa ligand. PLoS One 8:e57311 (2013). WB ; Human . PubMed: 23451202
  • Wang W  et al. Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats. Br J Pharmacol 169:1352-71 (2013). PubMed: 23647015
  • Zhang X  et al. Cholesterol metabolite, 5-cholesten-3ß-25-diol-3-sulfate, promotes hepatic proliferation in mice. J Steroid Biochem Mol Biol 132:262-70 (2012). WB ; Mouse . PubMed: 22732306
  • Chinetti-Gbaguidi G  et al. Human Atherosclerotic Plaque Alternative Macrophages Display Low Cholesterol Handling but High Phagocytosis Because of Distinct Activities of the PPAR{gamma} and LXRα Pathways. Circ Res : (2011). WB, IHC-Fr ; Human . PubMed: 21350215
  • Nedumaran B  et al. Orphan nuclear receptor DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis. J Biol Chem 285:9221-32 (2010). WB, ChIP ; Human . PubMed: 20080977

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