Anti-LXR alpha antibody [PPZ0412] - ChIP Grade (ab41902)

Mouse monoclonal LXR alpha antibody [PPZ0412]. Validated in WB, IP, ELISA, IHC, Flow Cyt, ChIP, ICC/IF and tested in Mouse, Rat, Human. Cited in 38 publication(s). Independently reviewed in 11 review(s).

Publishing research using ab41902? Please let us know so that we can cite the reference in this datasheet.

ab41902 has been referenced in 41 publications.

  • Gao Y  et al. LXRa Promotes the Differentiation of Human Gastric Cancer Cells through Inactivation of Wnt/ß-catenin Signaling. J Cancer 10:156-167 (2019). PubMed: 30662536
  • Becares N  et al. Impaired LXRa Phosphorylation Attenuates Progression of Fatty Liver Disease. Cell Rep 26:984-995.e6 (2019). PubMed: 30673619
  • Moreno-Santos I  et al. The Antagonist Effect of Arachidonic Acid on GLUT4 Gene Expression by Nuclear Receptor Type II Regulation. Int J Mol Sci 20:N/A (2019). PubMed: 30813326
  • El Kasmi KC  et al. Macrophage-derived IL-1ß/NF-?B signaling mediates parenteral nutrition-associated cholestasis. Nat Commun 9:1393 (2018). PubMed: 29643332
  • Feng T  et al. SIRT1 activator E1231 protects from experimental atherosclerosis and lowers plasma cholesterol and triglycerides by enhancing ABCA1 expression. Atherosclerosis 274:172-181 (2018). PubMed: 29787963
  • Zhang G  et al. Placental mechanism of prenatal nicotine exposure-reduced blood cholesterol levels in female fetal rats. Toxicol Lett 296:31-38 (2018). PubMed: 30036686
  • Jeong SJ  et al. Prdx1 (peroxiredoxin 1) deficiency reduces cholesterol efflux via impaired macrophage lipophagic flux. Autophagy 14:120-133 (2018). PubMed: 28605287
  • Bellomo C  et al. Snail mediates crosstalk between TGFß and LXRa in hepatocellular carcinoma. Cell Death Differ 25:885-903 (2018). PubMed: 29230000
  • Zhao XY  et al. Long noncoding RNA licensing of obesity-linked hepatic lipogenesis and NAFLD pathogenesis. Nat Commun 9:2986 (2018). PubMed: 30061575
  • Kim H The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophages. Sci Rep 7:7591 (2017). PubMed: 28790455
  • Xian X  et al. LRP1 integrates murine macrophage cholesterol homeostasis and inflammatory responses in atherosclerosis. Elife 6:N/A (2017). PubMed: 29144234
  • Nikolova V  et al. Changes in LXR signaling influence early-pregnancy lipogenesis and protect against dysregulated fetoplacental lipid homeostasis. Am J Physiol Endocrinol Metab 313:E463-E472 (2017). PubMed: 28420650
  • Song L  et al. Phytosterol esters attenuate hepatic steatosis in rats with non-alcoholic fatty liver disease rats fed a high-fat diet. Sci Rep 7:41604 (2017). WB ; Rat . PubMed: 28169366
  • Ikhlef S  et al. Human paraoxonase 1 overexpression in mice stimulates HDL cholesterol efflux and reverse cholesterol transport. PLoS One 12:e0173385 (2017). WB ; Mouse . PubMed: 28278274
  • Stein S  et al. Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease. J Clin Invest 127:583-592 (2017). PubMed: 28094767
  • Shrestha E  et al. Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages. J Biol Chem 291:11172-84 (2016). PubMed: 27026705
  • Sharma M  et al. Chemotherapy Agents Alter Plasma Lipids in Breast Cancer Patients and Show Differential Effects on Lipid Metabolism Genes in Liver Cells. PLoS One 11:e0148049 (2016). WB . PubMed: 26807857
  • Kim SY  et al. Liver X receptor and STAT1 cooperate downstream of Gas6/Mer to induce anti-inflammatory arginase 2 expression in macrophages. Sci Rep 6:29673 (2016). Mouse . PubMed: 27406916
  • Moreno M  et al. 3,5,3'-Triiodo-L-Thyronine- and 3,5-Diiodo-L-Thyronine- Affected Metabolic Pathways in Liver of LDL Receptor Deficient Mice. Front Physiol 7:545 (2016). WB ; Mouse . PubMed: 27909409
  • Bouttier M  et al. Alu repeats as transcriptional regulatory platforms in macrophage responses to M. tuberculosis infection. Nucleic Acids Res N/A:N/A (2016). Human . PubMed: 27604870
  • Sun X  et al. Insulin Dissociates the Effects of Liver X Receptor on Lipogenesis, Endoplasmic Reticulum Stress, and Inflammation. J Biol Chem 291:1115-22 (2016). WB . PubMed: 26511317
  • Zhao Y  et al. YiXin-Shu, a ShengMai-San-based traditional Chinese medicine formula, attenuates myocardial ischemia/reperfusion injury by suppressing mitochondrial mediated apoptosis and upregulating liver-X-receptor a. Sci Rep 6:23025 (2016). WB ; Mouse . PubMed: 26964694
  • Popineau L  et al. Novel Grb14-Mediated Cross Talk between Insulin and p62/Nrf2 Pathways Regulates Liver Lipogenesis and Selective Insulin Resistance. Mol Cell Biol 36:2168-81 (2016). WB ; Mouse . PubMed: 27215388
  • Dang F  et al. Fasting and Feeding Signals Control the Oscillatory Expression of Angptl8 to Modulate Lipid Metabolism. Sci Rep 6:36926 (2016). WB . PubMed: 27845381
  • Gabitova L  et al. Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR. Cell Rep 12:1927-38 (2015). PubMed: 26344763
  • Hussein MA  et al. LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2. PLoS One 10:e0135218 (2015). WB, ChIP . PubMed: 26288135
  • Xu Y  et al. Rutaecarpine suppresses atherosclerosis in ApoE-/- mice through upregulating ABCA1 and SR-BI within RCT. J Lipid Res 55:1634-47 (2014). PubMed: 24908654
  • Vinod M  et al. miR-206 controls LXRa expression and promotes LXR-mediated cholesterol efflux in macrophages. Biochim Biophys Acta 1841:827-35 (2014). WB ; Mouse, Human . PubMed: 24603323
  • Liang B  et al. Angiotensin-(1-7) upregulates expression of ABCA1 and ABCG1 through the Mas receptor via the liver X receptor alpha signaling pathway in THP-1 macrophages treated with Angiotensin II. Clin Exp Pharmacol Physiol N/A:N/A (2014). Human . PubMed: 25225013
  • He Q  et al. Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice. Cardiovasc Diabetol 13:149 (2014). Mouse . PubMed: 25416469
  • Zhao J  et al. Retinoic acid isomers facilitate apolipoprotein E production and lipidation in astrocytes through the retinoid X receptor/retinoic acid receptor pathway. J Biol Chem 289:11282-92 (2014). WB ; Human . PubMed: 24599963
  • A-Gonzalez N  et al. The nuclear receptor LXRa controls the functional specialization of splenic macrophages. Nat Immunol 14:831-9 (2013). WB ; Mouse . PubMed: 23770640
  • Feldmann R  et al. Genome-wide analysis of LXRa activation reveals new transcriptional networks in human atherosclerotic foam cells. Nucleic Acids Res 41:3518-31 (2013). WB, ChIP ; Human . PubMed: 23393188
  • Khan OM  et al. Targeting GGTase-I activates RHOA, increases macrophage reverse cholesterol transport, and reduces atherosclerosis in mice. Circulation 127:782-90 (2013). Mouse . PubMed: 23334894
  • Asquith DL  et al. The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release. Ann Rheum Dis N/A:N/A (2013). WB ; Human . PubMed: 23434566
  • Canavan M  et al. Activation of liver X receptor suppresses the production of the IL-12 family of cytokines by blocking nuclear translocation of NF-?Bp50. Innate Immun N/A:N/A (2013). PubMed: 24045337
  • Feldmann R  et al. Foam cell specific LXRa ligand. PLoS One 8:e57311 (2013). WB ; Human . PubMed: 23451202
  • Wang W  et al. Quercetin and allopurinol reduce liver thioredoxin-interacting protein to alleviate inflammation and lipid accumulation in diabetic rats. Br J Pharmacol 169:1352-71 (2013). PubMed: 23647015
  • Zhang X  et al. Cholesterol metabolite, 5-cholesten-3ß-25-diol-3-sulfate, promotes hepatic proliferation in mice. J Steroid Biochem Mol Biol 132:262-70 (2012). WB ; Mouse . PubMed: 22732306
  • Chinetti-Gbaguidi G  et al. Human Atherosclerotic Plaque Alternative Macrophages Display Low Cholesterol Handling but High Phagocytosis Because of Distinct Activities of the PPAR{gamma} and LXRα Pathways. Circ Res : (2011). WB, IHC-Fr ; Human . PubMed: 21350215
  • Nedumaran B  et al. Orphan nuclear receptor DAX-1 acts as a novel corepressor of liver X receptor alpha and inhibits hepatic lipogenesis. J Biol Chem 285:9221-32 (2010). WB, ChIP ; Human . PubMed: 20080977

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