Overview

  • Product name

    LY 2228820, p38 MAPK inhibitor
  • Description

    A novel and potent inhibitor of p38 MAPK
  • Alternative names

    • 5-[2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl]-3-(2,2-dimethylpropyl)imidazo[4,5-b]pyridin-2-amine;methanesulfonic acid
    • LY2228820 dimesylate
    • Mesylate
    • Ralimetinib
    • Ralimetinib dimesylate; 5-(2-(tert-butyl)-4-(4-fluorophenyl)-1H-imidazol-5-yl)-3-neopentyl-3H-imidazo[4,5-b]pyridin-2-amine dimethanesulfonate
    see all
  • Biological description

    LY 2228820 is a novel and potent p38 MAPK inhibitor with potent anti-inflammatory activity. It significantly inhibited phosphorylation of MAPKAPK2 and/or HSP27, down stream targets of p38MAPK, in both multiple myeloma (MM) cell lines and LT-BMSCs. LY 2228820 is a potential candidate to improve MM patient outcome both by enhancing the effect of Bortezomib (B675700) and by reducing osteoskeletal events. IC50 of 7 nM in a cell-free assay.

  • Purity

    > 98%
  • General notes

    Protect from air and light.

  • CAS Number

    862507-23-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-[2-(1,1-Dimethylethyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine Dimethanesulfonate

  • Molecular weight

    612.74
  • Molecular formula

    C26H37FN6O6S2
  • PubChem identifier

    11570805
  • Storage instructions

    Shipped at 4°C. Store at -20°C long term. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in water to 163.2 mM, in DMSO to 6.52 mM and in Ethanol to 4.89 mM

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)(C)CN1C2=C(C=CC(=N2)C3=C(N=C(N3)C(C)(C)C)C4=CC=C(C=C4)F)N=C1N.CS(=O)(=O)O.CS(=O)(=O)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Mader M  et al. Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties. Bioorg Med Chem Lett 18:179-83 (2008). Read more (PubMed: 18039577) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab143833.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up