LY 303511, PI3-kinase inhibitor (ab145193)

Overview

  • Product name

    LY 303511, PI3-kinase inhibitor
  • Description

    PI3-kinase inhibitor. Kv channel blocker.
  • Biological description

    PI3-kinase inhibitor. Kv channel blocker (IC50 = 64.6 μM). Negative control for and derivative of LY 294002 (ab120243). Inhibits IL-1β-stimulated NF-κB activation. Induces nuclear translocation of Hsp27. Inhibits BRD2, BRD3, and BRD4. Induces ROS production. Shows antiproliferative effects.
  • Purity

    > 98%
  • CAS Number

    154447-38-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    8-Phenyl-2-piperazin-1-ylchromen-4-one
  • Molecular weight

    306.36
  • Molecular formula

    C19H18N2O2
  • PubChem identifier

    3971
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM. Soluble in 1 eq. HCl to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CN(CCN1)C2=CC(=O)C3=C(O2)C(=CC=C3)C4=CC=CC=C4
  • Source

    Synthetic

References

This product has been referenced in:

  • Dittmann A  et al. The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains. ACS Chem Biol 9:495-502 (2014). Read more (PubMed: 24533473) »
  • Mellier G  et al. Small molecule sensitization to TRAIL is mediated via nuclear localization, phosphorylation and inhibition of chaperone activity of Hsp27. Cell Death Dis 4:e890 (2013). Read more (PubMed: 24176848) »
  • Tucker-Kellogg L  et al. Reactive oxygen species (ROS) and sensitization to TRAIL-induced apoptosis, in Bayesian network modelling of HeLa cell response to LY303511. Biochem Pharmacol 84:1307-17 (2012). Read more (PubMed: 22982511) »

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