LY-333531 hydrochloride, protein kinase Cbeta inhibitor (ab219866)

Overview

  • Product name

    LY-333531 hydrochloride, protein kinase Cbeta inhibitor
  • Description

    Potent, isozyme-selective protein kinase Cβ (PKCβ) inhibitor
  • Alternative names

    • LY333531 hydrochloride
    • Ruboxistaurin
    • Ruboxistaurin hydrochloride
  • Biological description

    Potent, isozyme-selective inhibitor of protein kinase Cβ (PKCβ). Competitively inhibits PKCßI and PKCßII (IC50 values are 4.7 and 5.9 nM respectively). 76- and 61-fold selective for inhibition of PKCßI and PKCßII in comparison to PKCα, respectively. Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).

  • Purity

    > 98%
  • CAS Number

    169939-93-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride
  • Molecular weight

    505.01
  • Molecular formula

    C28H28N4O3.HCl
  • PubChem identifier

    9870785
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO to 20 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C)C[C@@H]1CCN2C=C(C3=CC=CC=C32)C4=C(C5=CN(CCO1)C6=CC=CC=C65)C(=O)NC4=O.Cl
  • Source

    Synthetic

References

This product has been referenced in:

  • Ferreira JC  et al. ßIIPKC and ePKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failure. J Mol Cell Cardiol 51:479-84 (2011). Read more (PubMed: 21035454) »
  • Jirousek MR  et al. (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta. J Med Chem 39:2664-71 (1996). Read more (PubMed: 8709095) »

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