Key features and details
- Potent, isozyme-selective protein kinase Cβ (PKCβ) inhibitor
- CAS Number: 169939-93-9
- Purity: > 98%
- Soluble in DMSO to 20 mM
- Form / State: Solid
- Source: Synthetic
Product nameLY-333531 hydrochloride, protein kinase Cbeta inhibitor
DescriptionPotent, isozyme-selective protein kinase Cβ (PKCβ) inhibitor
- LY333531 hydrochloride
- Ruboxistaurin hydrochloride
Potent, isozyme-selective inhibitor of protein kinase Cβ (PKCβ). Competitively inhibits PKCßI and PKCßII (IC50 values are 4.7 and 5.9 nM respectively). 76- and 61-fold selective for inhibition of PKCßI and PKCßII in comparison to PKCα, respectively. Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src).
Chemical name(9S)-9-[(Dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione hydrochloride
Storage instructionsShipped at 4°C. Store at -20°C. Store under desiccating conditions.
Solubility overviewSoluble in DMSO to 20 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab219866 has not yet been referenced specifically in any publications.