LY 341495, Group II antagonist (ab120199)
- Datasheet
- References (11)
Overview
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Product nameLY 341495, Group II antagonist
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DescriptionPotent, selective group II antagonist. Group III antagonist at higher concentrations.
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Biological descriptionVery selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Kd values for human receptors are 1.67 (mGlu2), 0.75 (mGlu3), 31.6 (mGlu6), 72.7 (mGlu7a) and 14 nM (mGlu8a). IC50 values are 7.8, 8.2 and 22 μM for mGlu1a, mGlu5a and mGlu4 receptors, respectively. Readily brain penetrant and active in vivo.
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Purity> 98%
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General notes
Sold under license from Eli Lilly and company.
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CAS Number201943-63-7
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Chemical structure
Properties
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Chemical name(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl)propanoic acid
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Molecular weight353.37
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Molecular formulaC20H19NO5
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PubChem identifier9819927
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Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
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Solubility overviewSoluble in DMSO to 10 mM and in 1.2 eq. NaOH to 100 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILESO=C(O)[C@H]1C[C@@H]1[C@@](N)(CC2c4ccccc4Oc3ccccc23)C(=O)O
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Source
Synthetic
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Research areas
References
This product has been referenced in:
- Linden AM et al. Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495. Neuropharmacology 57:172-82 (2009). Read more (PubMed: 19477188) »
- Wright RA et al. Binding of [3H](2S,1'S,2'S)-2-(9-xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine ([3H]LY341495) to cell membranes expressing recombinant human group III metabotropic glutamate receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol 362:546-54 (2000). Read more (PubMed: 11138847) »
- Johnson BG et al. [3H]-LY341495 as a novel antagonist radioligand for group II metabotropic glutamate (mGlu) receptors: characterization of binding to membranes of mGlu receptor subtype expressing cells. Neuropharmacology 38:1519-29 (1999). Read more (PubMed: 10530814) »
- Kingston AE et al. LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors. Neuropharmacology 37:1-12 (1998). Read more (PubMed: 9680254) »
