LY 341495, Group II antagonist (ab120199)
Overview
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Product name
LY 341495, Group II antagonist -
Description
Potent, selective group II antagonist. Group III antagonist at higher concentrations. -
Biological description
Very selective nanomolar potent antagonist for group II mGlu receptors. Also a relatively potent antagonist for group III mGlu receptors at high nanomolar to low micromolar concentrations. Kd values for human receptors are 1.67 (mGlu2), 0.75 (mGlu3), 31.6 (mGlu6), 72.7 (mGlu7a) and 14 nM (mGlu8a). IC50 values are 7.8, 8.2 and 22 μM for mGlu1a, mGlu5a and mGlu4 receptors, respectively. Readily brain penetrant and active in vivo.
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Purity
> 98% -
CAS Number
201943-63-7 -
Chemical structure
Properties
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Chemical name
(2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl)propanoic acid -
Molecular weight
353.37 -
Molecular formula
C20H19NO5 -
PubChem identifier
9819927 -
Storage instructions
Store at Room Temperature. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM and in 1.2 eq. NaOH to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
O=C(O)[C@H]1C[C@@H]1[C@@](N)(CC2c4ccccc4Oc3ccccc23)C(=O)O -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (11)
ab120199 has been referenced in 11 publications.
- Mendis GDC et al. Discovering the pharmacodynamics of conolidine and cannabidiol using a cultured neuronal network based workflow. Sci Rep 9:121 (2019). PubMed: 30644434
- Bragina L et al. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals. Front Cell Neurosci 9:345 (2015). PubMed: 26388733
- Klar R et al. Activation of Metabotropic Glutamate Receptor 7 Is Required for Induction of Long-Term Potentiation at SC-CA1 Synapses in the Hippocampus. J Neurosci 35:7600-15 (2015). PubMed: 25972184
- Schauer C et al. Hypothalamic gonadotropin-releasing hormone (GnRH) receptor neurons fire in synchrony with the female reproductive cycle. J Neurophysiol 114:1008-21 (2015). PubMed: 26063780
- Yamada K et al. Neuronal activity regulates extracellular tau in vivo. J Exp Med 211:387-93 (2014). PubMed: 24534188
