Key features and details
- Group II mGlu agonist. Systemically active.
- CAS Number: 176199-48-7
- Purity: > 98%
- Soluble in 1 eq. NaOH to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameLY 354740, Group II mGlu agonist
DescriptionGroup II mGlu agonist. Systemically active.
Highly potent and selective agonist at mGlu2 and mGlu3 receptors (EC50 values are 5.1 and 24.3 nM, respectively). Displays no agonist or antagonist activity at mGlu1a, mGlu5a, mGlu4 or mGlu7 receptors at concentrations up to 100 μM. Orally and systemically active. Anxiolytic and antiaddictive effects in vivo.
Chemical name(1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in 1 eq. NaOH to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120173 has been referenced in 1 publication.
- Procaccini C et al. Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740. Neuroscience 250:189-200 (2013). PubMed: 23867766