Key features and details
- Group II mGlu agonist. Systemically active.
- CAS Number: 191471-52-0
- Purity: > 99%
- Soluble in water to 25 mM (with heating)
- Form / State: Solid
- Source: Synthetic
Product nameLY 379268, Group II mGlu agonist
DescriptionGroup II mGlu agonist. Systemically active.
Highly potent and systemically active mGlu2 and mGlu3 agonist. EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3, respectively and displays >80-fold selectivity over group I and group III receptors. Effective in several animal models of stroke, epilepsy, drug abuse, schizophrenia, and pain.
Chemical name(1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 25 mM (with heating)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120196 has been referenced in 6 publications.
- Bragina L et al. Differential expression of metabotropic glutamate and GABA receptors at neocortical glutamatergic and GABAergic axon terminals. Front Cell Neurosci 9:345 (2015). PubMed: 26388733
- Yin S et al. Selective actions of novel allosteric modulators reveal functional heteromers of metabotropic glutamate receptors in the CNS. J Neurosci 34:79-94 (2014). PubMed: 24381270
- Cuccurazzu B et al. Upregulation of mGlu2 Receptors via NF-?B p65 Acetylation Is Involved in the Proneurogenic and Antidepressant Effects of Acetyl-L-Carnitine. Neuropsychopharmacology 38:2220-30 (2013). PubMed: 23670591
- Klakotskaia D et al. Effects of group II and III metabotropic glutamate receptor ligands on conditioned taste aversion learning. Behav Brain Res 253:9-16 (2013). PubMed: 23827202
- Gosnell HB et al. mGluR8 modulates excitatory transmission in the bed nucleus of the stria terminalis in a stress-dependent manner. Neuropsychopharmacology 36:1599-607 (2011). PubMed: 21451497
- Rylander D et al. Pharmacological modulation of glutamate transmission in a rat model of L-DOPA-induced dyskinesia: effects on motor behavior and striatal nuclear signaling. J Pharmacol Exp Ther 330:227-35 (2009). PubMed: 19357321