LY2811376, Beta-secretase inhibitor (ab223884)

Overview

  • Product name

    LY2811376, Beta-secretase inhibitor
  • Description

    Selective Beta-secretase inhibitor
  • Alternative names

    • 1194044-20-6
  • Biological description

    LY2811376 is a selective Beta-secretase inhibitor (IC50 = 239 nM - 249 nM).

  • Purity

    > 99%
  • CAS Number

    1194044-20-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine
  • Molecular weight

    320.36
  • Molecular formula

    C15H14F2N4S
  • PubChem identifier

    44251605
  • Storage instructions

    Shipped at 4°C. Store at -20°C.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@]1(CCSC(=N1)N)C2=C(C=C(C(=C2)C3=CN=CN=C3)F)F
  • Source

    Synthetic

References

This product has been referenced in:

  • Vassar R  et al. Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. J Neurochem 130:4-28 (2014). Read more (PubMed: 24646365) »
  • May PC  et al. Robust central reduction of amyloid-ß in humans with an orally available, non-peptidic ß-secretase inhibitor. J Neurosci 31:16507-16 (2011). Read more (PubMed: 22090477) »
  • Yang HC  et al. Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1. J Neurochem 91:1249-59 (2004). Read more (PubMed: 15584902) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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