Overview

  • Product name

    LY2874455, FGF/FGFR inhibitor
  • Description

    Potent FGF/FGFR inhibitor
  • Alternative names

    • LY-2874455
  • Biological description

    Potent FGF/FGFR inhibitor. Inhibits in vitro autophosphorylation of FGFR-1, FGFR-2, FGFR-3, and FGFR-4 with similar inhibition potency for all four FGFRs (IC50 < 6.4 nM). Exhibits a 6- to 9-fold in vitro and in vivo selectivity on inhibition of FGF- over VEGF-mediated target signaling in mice.

  • Purity

    > 98%
  • CAS Number

    1254473-64-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol

  • Molecular weight

    444.31
  • Molecular formula

    C21H19Cl2N5O2
  • PubChem identifier

    46944259
  • Storage instructions

    Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    DMSO (>4 mg/ml)

  • SMILES

    Clc1cncc(Cl)c1[C@@H](C)Oc3cc4c(/C=C/c2cn(CCO)nc2)nnc4cc3
  • Source

    HPLC

References

This product has been referenced in:

  • Wu D  et al. Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455. PLoS One 11:e0162491 (2016). Read more (PubMed: 27618313) »
  • Zhao G  et al. A novel, selective inhibitor of fibroblast growth factor receptors that shows a potent broad spectrum of antitumor activity in several tumor xenograft models. Mol Cancer Ther 10:2200-10 (2011). Read more (PubMed: 21900693) »

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