LY2886721, BACE-1 inhibitor (ab223886)
Overview
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Product name
LY2886721, BACE-1 inhibitor -
Description
Potent and selective BACE-1 inhibitor -
Alternative names
- LY2886721
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Biological description
Potent and selective BACE-1 inhibitor (IC50 = 20.3 nM for recombinant hBACE-1). Human BACE2 is inhibited with an IC50 of 10.2 nM. Does not inhibit other aspartyl proteases such as cathepsin D, pepsin, and renin. A potential agent to treat Alzheimer’s Disease. Inhibits production of Aβ in HEK-293 Swe cells (IC50 values are 18.5 nM and 19.7 nM for Aβ1-40 and Aβ1-42 respectively) and in PDAPP neuronal cells (IC50 ~10 nM). Reduces dose-dependently brain levels of Aβ, C99 and sAPPβ in orally administered mouse model and plasma Aβ in dog model. Ppenetrates the blood-brain barrier.
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Purity
> 98% -
CAS Number
1262036-50-9 -
Chemical structure
Properties
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Chemical name
N-(3-((4aS,7aS)-2-Amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide
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Molecular weight
390.41 -
Molecular formula
C18H16F2N4O2S -
PubChem identifier
49837968 -
Storage instructions
Shipped at 4°C. Store at -20°C. Store In the Dark. Store under desiccating conditions. -
Solubility overview
Soluble in DMSO to 20 mM, in Ethanol < 2 mM
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SMILES
C1[C@H]2CSC(=N[C@]2(CO1)C3=C(C=CC(=C3)NC(=O)C4=NC=C(C=C4)F)F)N -
Source
Synthetic
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Research areas
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (0)
ab223886 has not yet been referenced specifically in any publications.
