Key features and details
- Potent Hedgehog signaling pathway inhibitor
- CAS Number: 1258861-20-9
- Soluble in DMSO to 100 mM with ultrasonic and warming
- Form / State: Solid
- Source: Synthetic
Product nameLY2940680 (Taladegib)
DescriptionPotent Hedgehog signaling pathway inhibitor
Potent Hedgehog signaling pathway inhibitor. Smoothened antagonist. Inhibits growth of cancer cell lines containing a disease-relevant Smoothened gene mutation. Has anti-tumor activity in animal models.
Chemical name4-Fluoro-N-methyl-N-[1-[4-(1-methyl-1H-pyrazol-5-yl)-1-phthalazinyl]-4- piperidinyl]-2-(trifluoromethyl)benzamide
Storage instructionsShipped at room temperature. Store at -20°C.
Solubility overviewSoluble in DMSO to 100 mM with ultrasonic and warming
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab269874 has not yet been referenced specifically in any publications.