Overview

  • Product name
    Anti-LY75 / DEC-205 antibody [RC38]
    See all LY75 / DEC-205 primary antibodies
  • Description
    Mouse monoclonal [RC38] to LY75 / DEC-205
  • Host species
    Mouse
  • Specificity
    RC38 stains over 95% of primary renal cell carcinomas and 60% of metastases of renal cell carcinoma and glomerular visceral epithelium and proximal tubules in normal kidney (cytoplasmic). It does not stain epithelial cells of non renal malignancies.
  • Tested applications
    Suitable for: IHC-Frmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Tissue, cells or virus corresponding to LY75/ DEC-205. A mouse was immunized with renal cell carcinoma homogenate. After fusing the spleen cells from this mouse with myeloma cells, antibody producing cells were screened on thin sections of human tissues.

  • General notes

    Previously labelled as LY75. 

Properties

Applications

Our Abpromise guarantee covers the use of ab2489 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-Fr 1/20.

Dilute 1/20 in PBS/1%BSA.

Target

  • Function
    Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment (By similarity). Causes reduced proliferation of B-lymphocytes.
  • Tissue specificity
    Expressed in spleen, thymus, colon and peripheral blood lymphocytes. Detected in myeloid and B lymphoid cell lines. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed-Sternberg (HRS) cells.
  • Sequence similarities
    Contains 10 C-type lectin domains.
    Contains 1 fibronectin type-II domain.
    Contains 1 ricin B-type lectin domain.
  • Post-translational
    modifications
    N-glycosylated.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • C-type lectin domain family 13 member B antibody
    • CD 205 antibody
    • CD205 antibody
    • CD205 antigen antibody
    • CLEC 13B antibody
    • CLEC13B antibody
    • DEC 205 antibody
    • DEC-205 antibody
    • DEC205 antibody
    • gp200 antibody
    • gp200 MR6 antibody
    • gp200-MR6 antibody
    • LY 75 antibody
    • Ly-75 antibody
    • LY75 antibody
    • LY75_HUMAN antibody
    • Lymphocyte antigen 75 antibody
    • Renal Cell Carcinoma (gp200) antibody
    see all

Images

  • ab2489 staining human renal cell carcinoma by Immunohistochemistry (frozen sections).

References

ab2489 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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