Product nameLysophosphatidic acid sodium salt, autophagy inhibitor
- 1-O-9Z-octadecenoyl-sn-glyceryl-3-phosphoric acid, sodium salt
- 1-Oleoyl-lysophosphatidic acid sodium salt
- LPA sodium salt
Endogenous agonist of the Lysophosphatidic acid (LPA) receptors. Induces cellular functions such as cell proliferation and migration, and ICAM-1, IL-8 and MCP-1 expression. Inhibits autophagy in cells under starvation conditions by inhibiting autophagosome formation.
1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid sodium salt
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Soluble in water to 20 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Lin CI et al. Lysophosphatidic acid regulates inflammation-related genes in human endothelial cells through LPA1 and LPA3. Biochem Biophys Res Commun 363:1001-8 (2007). Read more (PubMed: 17923111) »
- Ren J et al. Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells. Cancer Res 66:3006-14 (2006). Read more (PubMed: 16540649) »
- Levine JS et al. Lysophosphatidic acid: a novel growth and survival factor for renal proximal tubular cells. Am J Physiol 273:F575-85 (1997). Read more (PubMed: 9362335) »
- Moolenaar WH Lysophosphatidic acid, a multifunctional phospholipid messenger. J Biol Chem 270:12949-52 (1995). Read more (PubMed: 7768880) »
- van Corven EJ et al. Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin. Biochem J 281 ( Pt 1):163-9 (1992). Read more (PubMed: 1731751) »