Lysophosphatidic acid sodium salt, autophagy inhibitor (ab146430)

Overview

  • Product name

    Lysophosphatidic acid sodium salt, autophagy inhibitor
  • Description

    Autophagy inhibitor
  • Alternative names

    • 1-O-9Z-octadecenoyl-sn-glyceryl-3-phosphoric acid, sodium salt
    • 1-Oleoyl-lysophosphatidic acid sodium salt
    • LPA sodium salt
    • lysoPA
    • Oleoyl-lysophosphatidic acid sodium salt
    • Oleoyl-sn-3-glycerophosphate
    see all
  • Biological description

    Endogenous agonist of the Lysophosphatidic acid (LPA) receptors. Induces cellular functions such as cell proliferation and migration, and ICAM-1, IL-8 and MCP-1 expression. Inhibits autophagy in cells under starvation conditions by inhibiting autophagosome formation.

  • Purity

    > 98%
  • CAS Number

    22556-62-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid sodium salt

  • Molecular weight

    458.50
  • Molecular formula

    C21H40O7P.Na
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 20 mM (with warming)

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C(O[P](=O)(O)O)C(O)COC(=O)CCCCCCC\C=C/CCCCCCCC
  • Source

    Synthetic

References

This product has been referenced in:

  • Lin CI  et al. Lysophosphatidic acid regulates inflammation-related genes in human endothelial cells through LPA1 and LPA3. Biochem Biophys Res Commun 363:1001-8 (2007). Read more (PubMed: 17923111) »
  • Ren J  et al. Lysophosphatidic acid is constitutively produced by human peritoneal mesothelial cells and enhances adhesion, migration, and invasion of ovarian cancer cells. Cancer Res 66:3006-14 (2006). Read more (PubMed: 16540649) »
  • Levine JS  et al. Lysophosphatidic acid: a novel growth and survival factor for renal proximal tubular cells. Am J Physiol 273:F575-85 (1997). Read more (PubMed: 9362335) »
  • Moolenaar WH Lysophosphatidic acid, a multifunctional phospholipid messenger. J Biol Chem 270:12949-52 (1995). Read more (PubMed: 7768880) »
  • van Corven EJ  et al. Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin. Biochem J 281 ( Pt 1):163-9 (1992). Read more (PubMed: 1731751) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab146430.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up